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Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance

Molecular Psychiatry volume 12, pages 421–422 (2007)Cite this article

A Corrigendum to this article was published on 27 August 2007

There have been a large number of inconsistent reports of an association between a functional polymorphism (5HTTLPR), located in the promoter of the serotonin transporter gene, and susceptibility to depression and anxiety disorders.1 However, it is not known how many other sequence variants contribute to transcriptional variation of the serotonin transporter gene, nor whether their presence might confound interpretation of 5HTTLPR genetic association studies.

We explored these questions by measuring the relative abundance of allelic transcripts of the serotonin transporter gene by analysing heterozygoustranscribed polymorphisms in cell lines genotyped by the HapMap consortium. A quantitative analysis of the transcribed polymorphism will show an allelic expression imbalance (AEI) in those individuals who are heterozygote for both the transcribed variant and the cis-acting variant.

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References

  1. Munafo MR, Clark T, Flint J . Mol Psychiatry 2005; 10: 415–419.

  2. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD et al. Am J Hum Genet 2006; 78: 815–826.

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  4. Willis-Owen SA, Turri MG, Munafo MR, Surtees PG, Wainwright NW, Brixey RD et al. Biol Psychiatry 2005; 58: 451–456.

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Authors and Affiliations

  1. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    J Martin, J Cleak, J Flint & S Shifman

  2. National Heart and Lung Institute, London, UK

    S A G Willis-Owen

Authors
  1. J Martin
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  2. J Cleak
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  3. S A G Willis-Owen
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  4. J Flint
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  5. S Shifman
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Corresponding author

Correspondence to S A G Willis-Owen.

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Supplementary Information accompanies the paper on the Molecular Psychiatry website (http://www.nature.com/mp)

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Martin, J., Cleak, J., Willis-Owen, S. et al. Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Mol Psychiatry 12, 421–422 (2007). https://doi.org/10.1038/sj.mp.4001952

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