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  • Original Paper
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Regulation of Ets function by protein–protein interactions

Abstract

Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA binding domain, the ETS domain. Over 25 mammalian Ets family members control important biological processes, including cellular proliferation, differentiation, lymphocyte development and activation, transformation and apoptosis by recognizing the GGA core motif in the promoter or enhancer of their target genes. Protein–protein interactions regulates DNA binding, subcellular localization, target gene selection and transcriptional activity of Ets proteins. Combinatorial control is a characteristic property of Ets family members, involving interaction between Ets and other key transcriptional factors such as AP-1, NFκB and Pax family members. Specific domains of Ets proteins interact with many protein motifs such as bHLH, bZipper and Paired domain. Such interactions coordinate cellular processes in response to diverse signals including cytokines, growth factors, antigen and cellular stresses.

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Acknowledgements

This work was supported in part by National Institutes of Health Grants P01CA78582 to DK Watson and American Cancer Society Grant IRG97-151 to R Li. This article is dedicated to the memory of Dr Takis S Papas, a mentor, scientific colleague and friend.

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Li, R., Pei, H. & Watson, D. Regulation of Ets function by protein–protein interactions. Oncogene 19, 6514–6523 (2000). https://doi.org/10.1038/sj.onc.1204035

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