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Smoking molecular damage in bronchial epithelium

Oncogene volume 21, pages 7298–7306 (2002)Cite this article

Abstract

Our understanding of the molecular pathology of lung cancer is advancing rapidly with several specific genes and chromosomal regions being identified. Lung cancer appears to require many mutations in both dominant and recessive oncogenes to possess malignant phenotypes. Several genetic and epigenetic changes are common to all lung cancer histologic types, while others appear to be cell type specific. However, specific roles of the genes undergoing mutations and the order of cumulative molecular changes that lead to the development of each lung tumor histologic type remain to be fully elucidated. Recent findings of molecular abnormalities in normal appearing and preneoplastic bronchial epithelium from patients with lung cancer and chronic smokers suggest that genetic changes may serve as biomarkers for early diagnosis, risk assessment and monitoring response to chemoprevention.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, Santiago, P.O. Box 114-D, Chile

    Ignacio I Wistuba

  2. Department of Thoracic/Head and Neck Medical Oncology, Molecular Biology Laboratory, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, Texas, TX, USA

    Li Mao

  3. The Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, 75390, Texas, TX, USA

    Adi F Gazdar

  4. Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, 75390, Texas, TX, USA

    Adi F Gazdar

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  1. Ignacio I Wistuba
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  2. Li Mao
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  3. Adi F Gazdar
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Correspondence to Adi F Gazdar.

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Wistuba, I., Mao, L. & Gazdar, A. Smoking molecular damage in bronchial epithelium. Oncogene 21, 7298–7306 (2002). https://doi.org/10.1038/sj.onc.1205806

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