Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

Overexpression of KIT in chromophobe renal cell carcinoma

Oncogene volume 22, pages 847–852 (2003)Cite this article

Abstract

We analysed gene-expression profiles in 15 surgical specimens of conventional, papillary, and chromophobe renal cell carcinomas (RCCs) using high-density oligonucleotide arrays. From about 12 000 genes targeted by the array, 67 were upregulated specifically in each histological type of RCC. The oncogene KIT was one of the genes whose expression was upregulated specifically in chromophobe RCCs. Immunohistochemical analysis demonstrated the KIT gene product on the cell membrane of chromophobe RCC in all cases, although it was not detected in conventional RCCs or non-neoplastic kidneys except for weak staining in the cytoplasm of renal tubules. These results suggest that each histological subtype of RCC has a unique gene-expression profile, and in particular indicates for the first time that KIT could be a useful marker for chromophobe RCC. As overexpression of KIT might be involved in tumor growth, KIT could be a new therapeutic target in this special type of RCC.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Caruana G, Cambareri AC, Gonda TJ and Ashman LK . (1998). Oncogene, 16, 179–190.

  • Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ and Maxwell PH . (2000). J. Biol. Chem., 275, 25733–25741.

  • Dijkhuizen T, Van den Berg E, Van den Berg A, Storkel S, De Jong B, Seitz G and Henn W . (1996). Int. J. Cancer, 68, 47–50.

  • Freeman MR, Washecka R and Chung LW . (1989). Cancer Res., 49, 6221–6225.

  • Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U, Sugahara H, Butterfield JH, Ashman LK, Kanayama Y, Matsuzawa Y, Kitamura Y and Kanakura Y . (1993). J. Clin. Invest., 92, 1736–1744.

  • Gnerra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F and Duh FM . (1994). Nat. Genet., 7, 85–90.

  • Hibi K, Takahashi T, Sekido Y, Ueda R, Hida T, Ariyoshi Y, Takagi H and Takahashi T . (1991). Oncogene, 6, 2291–2296.

  • Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y and Kitamura Y . (1998). Science, 279, 577–580.

  • Ishikawa J, Maeda S, Umezu K, Sugiyama T and Kamidono S . (1990). Int. J. Cancer, 45, 1018–1021.

  • Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC and Conaway JW . (2000). Proc. Natl. Acad. Sci. USA, 97, 10430–10435.

  • Kenck C, Wilhelm M, Bugert P, Staehler G and Kovacs G . (1996). J. Pathol., 179, 157–161.

  • Kovacs G, Akhtar M, Beckwith BJ, Bugert P, Cooper CS, Delahunt B, Eble JN, Fleming S, Ljungberg B, Medeiros LJ, Moch H, Reuter VE, Ritz E, Roos G, Schmidt D, Srigley JR, Storkel S, van den Berg E and Zbar B . (1997). J. Pathol., 183, 131–133.

  • Kovacs A and Kovacs G . (1992). Genes Chromosomes Cancer, 4, 267–268.

  • Krystal GW, Honsawek S, Litz J and Buchdunger E . (2000). Clin. Cancer Res., 6, 3319–3326.

  • Nakopoulou L, Vouriakou C, Papaliodi E, Lazaris AC, Stefanaski K and Michalopoulos G . (1997). Pathol. Res. Pract., 193, 299–304.

  • Natali PG, Prat M, Nicotra MR, Bigotti A, Olivero M, Comoglio PM and Di Renzo MF . (1996). Int. J. Cancer, 69, 212–217.

  • Nishida T, Hirota S, Taniguchi M, Hashimoto K, Isozaki K, Nakamura H, Kanakura Y, Tanaka T, Takabayashi A, Matsuda H and Kitamura Y . (1998). Nat Genet., 19, 323–324.

  • Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD and Fletcher JA . (2001). Cancer Res., 61, 8118–8121.

  • Schmidt L, Duh FM, Chen F, Kishida T, Glenn G, Choyke P, Scherer SW, Zhuang Z, Lubensky I, Dean M, Allikmets R, Chidambaram A, Bergerheim UR, Feltis JT, Casadevall C, Zamarron A, Bernues M, Richard S, Lips CJ, Walther MM, Tsui LC, Geil L, Orcutt ML, Stackhouse T and Zbar B . (1997). Nat. Genet., 16, 68–73.

  • Schmidt L, Junker K, Nakaigawa N, Kinjerski T, Weirich G, Miller M, Lubensky I, Neumann HP, Brauch H, Decker J, Vocke C, Brown JA, Jenkins R, Richard S, Bergerheim U, Gerrard B, Dean M, Linehan WM and Zbar B . (1999). Oncogene, 18, 2343–2350.

  • Semenza GL . (2000). Crit. Rev. Biochem. Mol. Biol., 35, 71–103.

  • Speicher MR, Schoell B, du Manoir S, Schrock E, Ried T, Cremer T, Storkel S, Kovacs A and Kovacs G . (1994). Am. J. Pathol., 145, 356–364.

  • Storkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG, Darson M, Delahunt B and Iczkowski K . (1997). Cancer, 80, 987–989.

  • Takahashi M, Rhodes DR, Furge KA, Kanayama H, Kagawa S, Haab BB and Teh BT . (2001). Proc. Natl. Acad. Sci. USA, 98, 9754–9759.

  • Tanimoto K, Makino Y, Pereira T and Poellinger L . (2000). EMBO J., 19, 4298–4309.

  • Thoenes W, Storkel S and Rumpelt HJ . (1986). Pathol Res. Pract., 181, 125–143.

  • Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA and Demetri GD . (2001). Oncogene, 20, 5054–5058.

  • Wang WL, Healy ME, Satlier M, Verma S, Lin J, Maulik G, Stiles CD, Griffin JD, Johnson BE and Salgia R . (2000). Oncogene, 19, 3521–3528.

  • Young AN, Amin MB, Moreno CS, Lim SD, Cohen C, Petros JA, Marshall FF and Neish AS . (2001). Am. J. Pathol., 158, 1639–1651.

Download references

Acknowledgements

This study was supported by the Program for Promotion of Fundamental Studies in Health Sciences of the Organization for Parmaceutical Safety and Research, Japan.

Author information

Authors and Affiliations

  1. Cancer Genomics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuou-ku, Tokyo, 104-0045, Japan

    Ken Yamazaki, Tsutomu Ohta & Misao Ohki

  2. The Organization for Pharmaceutical Safety and Research, Shin-Kasumigaseki Bldg. 9F, 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo, 100-0013, Japan

    Ken Yamazaki

  3. Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-0016, Japan

    Michiie Sakamoto

  4. Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuou-ku, Tokyo, 104-0045, Japan

    Michiie Sakamoto, Yae Kanai & Setsuo Hirohashi

Authors
  1. Ken Yamazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michiie Sakamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tsutomu Ohta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yae Kanai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Misao Ohki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Setsuo Hirohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michiie Sakamoto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamazaki, K., Sakamoto, M., Ohta, T. et al. Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene 22, 847–852 (2003). https://doi.org/10.1038/sj.onc.1206153

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1206153

Keywords

This article is cited by

Search

Advanced search

Quick links