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An essential role for protein synthesis in oncogenic cellular transformation

Oncogene volume 23, pages 3145–3150 (2004)Cite this article

Abstract

The induction and maintenance of oncogenic transformation requires interference with the controls that regulate translation and transcription. The PI 3-kinase pathway, which shows gain of function in numerous and diverse human cancers, generates signals that have a positive effect on the initiation of protein synthesis. Here we review the components of the PI 3-kinase signaling pathway and the mRNA-binding protein YB-1, exploring their roles in protein synthesis and oncogenic cell transformation.

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Abbreviations

BRCA1:

breast cancer susceptibility gene product

eIF4E:

eucaryotic initiation factor 4E

IκB:

inhibitor of NFκB

IKK:

IκB kinase

mRNP:

messenger ribonucleoprotein particle

NFκB:

nuclear factor κB

PI3K:

phosphoinositide 3-kinase

PTEN:

phosphatase and tensin homolog deleted on chromosome 10

Raptor:

regulatory associated protein of TOR

Rheb:

Ras homolog enriched in brain

TOR:

target of rapamycin

TOS:

TOR signaling

TSC:

tuberous sclerosis complex

YB-1:

Y box-binding protein 1

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Acknowledgements

Research of the authors is supported by grants from the National Cancer Institute, National Institutes of Health and the Austrian Science Foundation (FWF). This is manuscript number 16175-MEM from The Scripps Research Institute.

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  1. Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Andreas G Bader & Peter K Vogt

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Bader, A., Vogt, P. An essential role for protein synthesis in oncogenic cellular transformation. Oncogene 23, 3145–3150 (2004). https://doi.org/10.1038/sj.onc.1207550

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