Abstract
Src family nonreceptor tyrosine kinases are an integral component of the signal transduction apparatus employed by growth factor receptor tyrosine kinases. As such, their role in cellular growth control and malignant transformation has been the subject of intensive investigation. In contrast, classical G-protein-coupled receptor (GPCR) signaling involves activation of second messenger-regulated serine/threonine kinases or ion channels, and is primarily involved in neurotransmission and the short-term regulation of intermediary metabolism. Over the past decade, this strictly dichotomous model of transmembrane signaling has been challenged by the discovery that GPCRs also exert control over cellular growth, proliferation, and differentiation, and do so by stimulating tyrosine phosphorylation cascades. Several mechanisms, from the direct association of Src family kinases with GPCRs or receptor-associated proteins, to the transactivation of receptor tyrosine kinases and focal adhesion complexes by G-protein-mediated signals, permit GPCRs to activate Src family kinases. Conversely, Src activity plays a central role in controlling GPCR trafficking and effects on cell proliferation and cytoskeletal rearrangement. It is now clear that GPCRs and Src family kinases do not belong to separate, exclusive clubs. Rather, these strange bedfellows are intimately involved in multilayered forms of crosstalk that influence a host of cellular processes.
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Abbreviations
- CSK:
-
C-terminal Src kinase
- EGF:
-
epidermal growth factor
- ERK:
-
extracellular signal-regulated kinase
- FAK:
-
focal adhesion kinase
- GEF:
-
guanine nucleotide exchange factor
- GPCR:
-
G-protein-coupled receptor
- G protein:
-
heterotrimeric guanine nucleotide-binding protein
- GRK:
-
G-protein-coupled receptor kinase
- HB-EGF:
-
heparin-binding EGF
- JNK:
-
c-Jun N-terminal kinase
- LPA:
-
lysophosphatidic acid
- MAP:
-
mitogen-activated protein
- MMP:
-
matrix metalloprotease
- PDGF:
-
platelet-derived growth factor
- PKA:
-
protein kinase A
- PKC:
-
protein kinase C
- TGFα:
-
transforming growth factor α
- SH2:
-
Src homology domain 2
- SH3:
-
Src homology domain 3
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Acknowledgements
The research in the authors' laboratory is supported by grants from the National Institutes of Health DK55524, DK58283, and DK64353 (to LML).
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Luttrell, D., Luttrell, L. Not so strange bedfellows: G-protein-coupled receptors and Src family kinases. Oncogene 23, 7969–7978 (2004). https://doi.org/10.1038/sj.onc.1208162
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