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Cell cycle in mouse development

Oncogene volume 24, pages 2877–2898 (2005)Cite this article

Abstract

Mice likely represent the most-studied mammalian organism, except for humans. Genetic engineering in embryonic stem cells has allowed derivation of mouse strains lacking particular cell cycle proteins. Analyses of these mutant mice, and cells derived from them, facilitated the studies of the functions of cell cycle apparatus at the organismal and cellular levels. In this review, we give some background about the cell cycle progression during mouse development. We next discuss some insights about in vivo functions of the cell cycle proteins, gleaned from mouse knockout experiments. Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list.

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Acknowledgements

This work was supported by grants from the State Committee for Scientific Research (KBN) to MAC (3P04C 002 25) and a Grant R01 CA085296 from NIH to PS.

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  1. Department of Embryology, Institute of Zoology, Faculty of Biology, Warsaw University, Miecznikowa 1, 02-096, Warsaw, Poland

    Maria A Ciemerych

  2. Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA, 02115, USA

    Peter Sicinski

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Ciemerych, M., Sicinski, P. Cell cycle in mouse development. Oncogene 24, 2877–2898 (2005). https://doi.org/10.1038/sj.onc.1208608

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