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Cyclin E in normal and neoplastic cell cycles

Abstract

Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.

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Acknowledgements

We thank Jim Roberts and members of the Clurman lab for critical review of this paper. Work in the author's lab is supported by NIH Grants R01CA84069 and R01CA102742 (BEC) and K08HL073670 (HH). BEC is a WM Keck Distinguished Young Investigator in Medical Research.

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Hwang, H., Clurman, B. Cyclin E in normal and neoplastic cell cycles. Oncogene 24, 2776–2786 (2005). https://doi.org/10.1038/sj.onc.1208613

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