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Global epidemiology of HTLV-I infection and associated diseases

Abstract

Epidemiologic aspects of human T-lymphotropic virus type I (HTLV-I) infection have been thoroughly studied over the course of approximately 25 years since its first description. The geographic distribution of the virus has been defined, with Japan, Africa, Caribbean islands and South America emerging as the areas of highest prevalence. The reasons for HTLV-I clustering, such as the high ubiquity in southwestern Japan but low prevalence in neighboring regions of Korea, China and eastern Russia are still unknown. The major modes of transmission are well understood, although better quantitative data on the incidence of transmission, and on promoting/inhibiting factors, are needed. Epidemiologic proof has been obtained for HTLV-I's causative role in major disease associations: adult T-cell leukemia (ATL), HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), HTLV-associated uveitis and infective dermatitis. However, more and better studies are needed for other apparent disease outcomes such as rheumatologic, psychiatric and infectious diseases. Since curative treatment of ATL and HAM/TSP is lacking and a vaccine is unavailable, the social and financial cost for the individual, his/her family and the health system is immense. For this reason, public health interventions aimed at counseling and educating high-risk individuals and populations are of paramount importance.

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References

  • Andersson S, Dias F, Mendez PJ, Rodrigues A and Biberfeld G . (1997). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 15, 320–322.

  • Bangham CR . (2003). J. Gen. Virol., 84, 3177–3189.

  • Barmak K, Harhaj E, Grant C, Alefantis T and Wigdahl B . (2003). Virology, 308, 1–12.

  • Bartholomew C, Jack N, Edwards J, Charles W, Corbin D, Cleghorn FR and Blattner WA . (1998). J. Hum. Virol., 1, 302–305.

  • Bartholomew C, Saxinger WC, Clark JW, Gail M, Dudgeon A, Mahabir B, Hull-Drysdale B, Cleghorn F, Gallo RC and Blattner WA . (1987). JAMA, 257, 2604–2608.

  • Beilke MA, In DR, Gravell M, Hamilton RS, Mora CA, Leon-Monzon M, Rodgers-Johnson PE, Gajdusek DC, Gibbs Jr CJ and Zaninovic V . (1991). J. Med. Virol., 33, 64–71.

  • Beilke MA, Traina-Dorge V, England JD and Blanchard JL . (1996). Arthritis Rheum., 39, 610–615.

  • Belza MJ . (2004). Eur. J. Epidemiol., 19, 279–282.

  • Bhagavati S, Ehrlich G, Kula RW, Kwok S, Sninsky J, Udani V and Poiesz BJ . (1988). N. Engl. J. Med., 318, 1141–1147.

  • Bittencourt AL, Dourado I, Filho PB, Santos M, Valadao E, Alcantara LC and Galvao-Castro B . (2001). J. Acq. Immun. Def. Synd., 26, 490–494.

  • Blattner WA . (1990). Human Retrovirology: HTLV Blattner WA (ed). Raven Press: New York, pp. 251–263.

    Google Scholar 

  • Blattner WA, Nomura A, Clark JW, Ho GY, Gallo NR and Robert-Guroff M . (1986). Proc. Natl. Acad. Sci. USA, 83, 4895–4898.

  • Carneiro-Proietti AB, Catalan-Soares B and Proietti FA . (2002). J. Biomed. Sci., 9, 587–595.

  • Castillo LC, Gracia F, Roman GC, Levine P, Reeves WC and Kaplan J . (2000). Acta. Neurol. Scand., 101, 405–412.

  • Catalan-Soares B, Carneiro-Proietti AB and Proietti FA . (2004). Rev. Panam. Salud. Publica., 16, 387–394.

  • Catalan-Soares BC, Carneiro-Proietti ABF and Proietti FA . (2003). Rev. Saude. Publica., 37, 470–476.

  • Catovsky D, Greaves MF, Rose M, Galton DA, Goolden AW, McCluskey DR, White JM, Lampert I, Bourikas G, Ireland R, Brownell AI, Bridges JM, Blattner WA and Gallo RC . (1982). Lancet, 1, 639–643.

  • Chavance M, Frery N, Valette I, Schaffar-Deshayes L and Monplaisir N . (1990). Am. J. Epidemiol., 131, 395–399.

  • Chiavetta JA, Escobar M, Newman A, He Y, Driezen P, Deeks S, Hone DE, O'Brien SF and Sher G . (2003). Can. Med. Assoc. J., 169, 767–773.

  • Courouce AM, Pillonel J, Lemaire JM, Maniez M and Brunet JB . (1993). Aids, 7, 841–847.

  • Cruikshank EK . (1956). West Indian Med. J., 5, 147–158.

  • de The G and Kazanji M . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 13 (Suppl 1), S191–S198.

  • DeVita DA, Guiltinan AM and Murphy EL . (2003). AIDS Res. Hum. Retroviruses, 19, S-46.

  • Donegan E, Busch MP, Galleshaw JA, Shaw GM and Mosley JW . (1990). Ann. Intern. Med., 113, 555–556.

  • Dumas M, Houinato D, Verdier M, Zohoun T, Josse R, Bonis J, Zohoun I, Massougbodji A and Denis F . (1991). AIDS Res. Hum. Retroviruses, 7, 447–451.

  • Eguchi K, Nakamura T, Mine M, Ida H, Kawakami A, Migita K, Nagasato K, Kurata A, Fukuda T and Nagataki S . (1992). Ann. Rheum. Dis., 51, 673–677.

  • Eguchi K, Origuchi T, Takashima H, Iwata K, Katamine S and Nagataki S . (1996). Arthritis Rheum., 39, 463–466.

  • Ehrlich GD, Andrews J, Sherman MP, Greenberg SJ and Poiez BJ . (1992). Virology, 186, 619–627.

  • Ehrlich GD and Poiesz BJ . (1988). Clin. Lab. Med., 8, 65–84.

  • Eiraku N, Novoa P, da Costa Ferreira M, Monken C, Ishak R, da Costa Ferreira O, Zhu SW, Lorenco R, Ishak M, Azvedo V, Guerreiro J, de Oliveira MP, Loureiro P, Hammerschlak N, Ijichi S and Hall WM . (1996). J. Virol., 70, 1481–1492.

  • Etzel A, Shibata GY, Rozman M, Jorge ML, Damas CD and Segurado AA . (2001). J. Acq. Immun. Def. Synd., 26, 185–190.

  • Feigal E, Murphy E, Vranizan K, Bacchetti P, Chaisson R, Drummond JE and Blattner WA . (1991). J. Infect. Dis., 164, 36–42.

  • Ferreira Jr OC, Planelles V and Rosenblatt JD . (1997). Blood Rev., 11, 91–104.

  • Figueroa JP, Ward E, Morris J, Brathwaite AR, Peruga A, Blattner W, Vermund SH and Hayes R . (1997). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 15, 232–237.

  • Fouchard N, Mahe A, Huerre M, Fraitag S, Valensi F, Macintyre E, Sanou F, de The G and Gessain A . (1998). Leukemia, 12, 578–585.

  • Freitas V, Gomes I, Bittencourt A, Fernandes D and Melo A . (1997). Arq. Neuropsiquiatr., 55, 325–328.

  • Fujino T, Iwamoto I, Otsuka H, Ikeda T, Takesako S and Nagata Y . (1999). Obstet. Gynecol., 94, 279–283.

  • Fujino T and Nagata Y . (2000). J. Reprod. Immunol., 47, 197–206.

  • Fujiyoshi T, Yashiki S, Fujiyama C, Kuwayama M, Miyashita H, Ohnishi H, Blank M, Zaninovic V, Blank A and Cartier L . (1995). Int. J. Cancer, 63, 510–515.

  • Gabet AS, Mortreux F, Talarmin A, Plumelle Y, Leclercq I, Leroy A, Gessain A, Clity E, Joubert M and Wattel E . (2000). Oncogene, 19, 4954–4960.

  • Gallo RC . (1973). Am. J. Clin. Pathol., 60, 80–87.

  • Galvao-Castro B, Loures L, Rodriques LG, Sereno A, Ferreira Junior OC, Franco LG, Muller M, Sampaio DA, Santana A, Passos LM and Proietti F . (1997). Transfusion, 37, 242–243.

  • Gastaldello R, Hall WW and Gallego S . (2004). J. Acq. Immun. Def. Synd., 35, 301–308.

  • Gerard Y, Lepere JF, Pradinaud R, Joly F, Lepelletier L, Joubert M, Sainte Marie D, Mahieux R, Vidal AU, Larregain-Fournier D, Valensi E, Moynet D, De Thé G, Guillemain B, Moreau J and Gessain A . (1995). Int. J. Cancer, 60, 773–776.

  • Gessain A and de The G . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol, 13 (Suppl 1), S228–S235.

  • Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A and de The G . (1985). Lancet, 2, 407–410.

  • Gessain A, Caudie C, Gout O, Vernant JC, Maurs L, Giordano C and Malone G . (1988). J. Infect. Dis., 157, 1226–1234.

  • Gessain A, Gallo RC and Franchini G . (1992). J. Virol., 66, 2288–2295.

  • Gessain A, Yanagihara R, Franchini G, Garruto RM, Jenkins CL, Ajdukiewicz AB, Gallo RC and Gajdusek DC . (1991). Proc. Natl. Acad. Sci. USA, 88, 7694–7698.

  • Gibbs WN, Lofters WS, Campbell M, Hanchard B, LaGrenade L, Cranston B and Hedriks J . (1987). Ann. Intern. Med., 106, 361–368.

  • Goncalves DU, Guedes AC, Carneiro-Proietti AB, Pinheiro SR, Catalan-Soares B, Proietti FA and Lambertucci JR . (1999). Int. J. STD AIDS, 10, 336–337.

  • Goto K, Saeki K, Kurita M, Iijima Y, Miyake A and Ohno S . (1994). Jpn. J. Ophthalmol., 38, 175–177.

  • Gout O, Baulac M, Gessain A, Semah F, Saal F, Peries J, Cabrol C, Foucault-Fretz C, Laplane D, Sigaux F and Thé GD . (1990). N. Engl. J. Med., 322, 383–388.

  • Guiltinan AM, Murphy EL, Horton JA, Nass CC, McEntire RL and Watanabe K . (1998). Transfusion, 38, 1056–1062.

  • Hanchard B . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 13 (Suppl 1), S20–S25.

  • Hanchard B, Gibbs WN, Lofters W, Campbell M, Williams E, Williams N, Jaffe E, Cranston B, Panchoosingh LD, LaGrenade L, Wilks R, Murphy E, Blattner W and Manns A . (1990). Human Retrovirology: HTLV. Blattner WA (ed). Raven Press: New York, pp. 173–183.

    Google Scholar 

  • Hayashi J, Kishihara Y, Yoshimura E, Furusyo N, Yamaji K, Kawakami Y, Murakami H and Kashiwagi S . (1997). Am. J. Trop. Med. Hyg., 56, 71–75.

  • Hino S, Katamine S, Miyata H, Tsuji Y, Yamabe T and Miyamoto T . (1997). Leukemia, 11 (Suppl 3), 57–59.

  • Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI and Shirakawa S . (1981). Proc. Natl. Acad. Sci. USA, 78, 6476–6480.

  • Hisada M, Okayama A, Shioiri S, Spiegelman DL, Stuver SO and Mueller NE . (1998). Blood, 92, 3557–3561.

  • Iannone R, Sherman MP, Rodgers-Johnson PE, Beilke MA, Mora CA, Amin RM, Tinsley SR, Papsidero LD, Poiesz BJ and Gibbs Jr CJ . (1992). J. Acq. Immun. Def. Synd., 5, 810–816.

  • Ijichi S, Matsuda T, Maruyama I, Izumihara T, Kojima K, Niimura T, Maruyama Y, Sonoda S, Yoshida A and Osame M . (1990). Ann. Rheum. Dis., 49, 718–721.

  • Inose M, Higuchi I, Yoshimine K, Suehara M, Izumo S, Arimura K and Osame M . (1992). J. Neurol. Sci., 110, 73–78.

  • Ishak R, Vallinoto AC, Azevedo VN and Ishak Mde O . (2003). Cad. Saude. Publica., 19, 901–914.

  • Ishikawa T . (2003). Int. J. Hematol., 78, 304–311.

  • Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I, Nishioka K, Yamamoto K, Takeda T and Hatanaka M . (1991). Science, 253, 1026–1028.

  • Iwasaki Y . (1990). J. Neurol. Sci., 96, 103–123.

  • Jeffery KJ, Usuku K, Hall SE, Matsumoto W, Taylor GP, Procter J, Bunce M, Ogg GS, Welsh KI, Weber JN, Lloyd AL, Nowak MA, Nagai M, Kodama D, Izumo S, Osame M and Bangham CR . (1999). Proc. Natl. Acad. Sci. USA, 96, 3848–3853.

  • Kajiyama W, Kashiwagi S, Ikematsu H, Hayashi J, Nomura H and Okochi K . (1986). J. Infect. Dis., 154, 851–857.

  • Kaplan JE, Khabbaz RF, Murphy EL, Hermansen S, Roberts C, Lal R, Heneine W, Wright D, Matijas L, Thomson R, Rudolph D, Switzer WM, Kleinman S, Busch M and Schreiber GB . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 12, 193–201.

  • Kasahata N, Kawamura M, Shiota J, Miyazawa Y, Suzuki Y and Sugita K . (2000). No To Shinkei, 52, 1003–1006.

  • Kawai H, Inui T, Kashiwagi S, Tsuchihashi T, Masuda K, Kondo A, Niki S, Iwasa M and Saito S . (1992). J. Med. Virol., 38, 138–141.

  • Kawai H, Nishida Y, Takagi M, Nakamura S and Saito S . (1989). Rinsho. Shinkeigaku., 29, 588–592.

  • Kazanji M and Gessain A . (2003). Cad. Saude. Publica., 19, 1227–1240.

  • Khabbaz RF, Onorato IM, Cannon RO, Hartley TM, Roberts B, Hosein B and Kaplan JE . (1992). N. Engl. J. Med., 326, 375–380.

  • Kimura I . (1992). Nihon. Kyobu. Shikkan. Gakkai. Zasshi., 30, 787–795.

  • Kinoshita K, Hino S, Amagaski T, Ikeda S, Yamada Y, Suzuyama J, Momita S, Toriya K, Kamihira S and Ichimaru M . (1984). Gann, 75, 103–105.

  • Koralnik IJ, Boeri E, Saxinger WC, Monico AL, Fullen J, Gessain A and Guo HG . (1994). J. Virol., 68, 2693–2707.

  • Kramer A, Maloney EM, Morgan OS, Rodgers-Johnson P, Manns A, Murphy EL, Larsen S, Cranston B, Murphy J, Benichou J and Blattner WA . (1995). Am. J. Epidemiol., 142, 1212–1220.

  • La Grenade L . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 13 (Suppl 1), S46–S49.

  • LaGrenade L, Hanchard B, Fletcher V, Cranston B and Blattner W . (1990). Lancet, 336, 1345–1346.

  • Larsen O, Andersson S, da Silva Z, Hedegaard K, Sandstrom A, Naucler A, Dias F, Melbye M and Aaby P . (2000). J. Acq. Immun. Def. Synd., 25, 157–163.

  • Lee H, Swanson P, Shorty VS, Zack JA, Rosenblatt JD and Chen IS . (1989). Science, 244, 471–475.

  • Lee HH, Weiss SH, Brown LS, Mildvan D, Shorty V, Saravolatz L and Chu A . (1990). J. Infect. Dis., 162, 347–352.

  • Lehky TJ, Fox CH, Koenig S, Levin MC, Flerlage N, Izumo S, Sato E, Raine CS, Osame M and Jacobson S . (1995). Ann. Neurol., 37, 167–175.

  • Leon G, Quiros AM, Lopez JL, Hung M, Diaz AM, Goncalves J, Da Costa O, Hernandez T, Chirinos M and Gomez R . (2003). Rev. Panam. Salud. Publica., 13, 117–123.

  • Li H, Hisada M, Yamano Y, Maloney E, Yao K, Hanchard B, Morgan O and Jacobson S . (2003). AIDS Res. Hum. Retroviruses, 19, P9.

  • Liu H, Leung P, Glynn S and Murphy EL . (2001). Virology, 279, 90–96.

  • Mahieux R, Horal P, Mauclere P, Mercereau-Puijalon O, Guillotte M, Meertens L, Murphy E and Gessain A . (2000). J. Clin. Microbiol., 38, 4049–4057.

  • Mahieux R, Pecon-Slattery J and Gessain A . (1997). J. Virol., 71, 6253–6258.

  • Maloney EM, Cleghorn FR, Morgan OS, Rodgers-Johnson P, Cranston B, Jack N, Blattner WA, Bartholomew C and Manns A . (1998). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 17, 167–170.

  • Maloney EM, Murphy EL, Figueroa JP, Gibbs WN, Cranston B, Hanchard B and Holding-Cobham M . (1991). Am. J. Epidemiol., 133, 1125–1134.

  • Manns A and Blattner WA . (1991). Transfusion, 31, 67–75.

  • Manns A, Hisada M and La Grenade L . (1999). Lancet, 353, 1951–1958.

  • Manns A, Wilks RJ, Murphy EL, Haynes G, Figueroa JP, Barnett M and Hanchard B . (1992). Int. J. Cancer, 51, 886–891.

  • Marsh BJ . (1996). Clin. Infect. Dis., 23, 138–145.

  • Mathieux R and Gessain A . (2003). Rev. Clin. Exp. Hematol., 7, 336–361.

  • Matutes E, Schulz T, Serpa MJ, de Queiroz-Campos-Araujo A and de Oliveira MS . (1994). Leukemia, 8, 1092–1094.

  • Mauclere P, Le Hesran JY, Mahieux R, Salla R, Mfoupouendoun J, Abada ET, Millan J, de The G and Gessain A . (1997). J. Infect. Dis., 176, 505–509.

  • Mbanya DN, Takam D and Ndumbe PM . (2003). Transfus. Med., 13, 267–273.

  • McCallum RM, Patel DD, Moore JO and Haynes BF . (1997). Med. Clin. North Am., 81, 261–276.

  • McKhann II G, Gibbs Jr CJ, Mora CA, Rodgers-Johnson PE, Liberski PP, Gdula WJ and Zaninovic V . (1989). J. Infect. Dis., 160, 371–379.

  • Miller GJ, Lewis LL, Colman SM, Cooper JA, Lloyd G, Scollen N, Jones N, Tedder RS and Greaves MF . (1994). J. Infect. Dis., 170, 44–50.

  • Miller GJ, Pegram SM, Kirkwood BR, Beckles GL, Byam NT, Clayden SA, Kinlen LJ, Chan LC, Carson DC and Greaves MF . (1986). Int. J. Cancer, 38, 801–808.

  • Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K and Hinuma Y . (1981a). Nature, 294, 770–771.

  • Miyoshi I, Miyamoto K, Sumida M, Nishihara R, Lai M, Yoshimoto S and Sato J . (1981b). Cancer Genet. Cytogenet., 3, 251–259.

  • Mochizuki M, Watanabe T, Yamaguchi K, Tajima K, Yoshimura K, Nakashima S, Shirao M, Araki S, Miyata N, Mori S and Takatsuki K . (1992). J. Infect. Dis., 166, 943–944.

  • Mueller N . (1991). Cancer Causes Control, 2, 37–52.

  • Mueller N, Okayama A, Stuver S and Tachibana N . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 13 (Suppl 1), S2–S7.

  • Murphy EL, Figueroa JP, Gibbs WN, Brathwaite A, Holding-Cobham M, Waters D and Cranston B . (1989a). Ann. Intern. Med., 111, 555–560.

  • Murphy EL, Figueroa JP, Gibs WN, Holding-Cobham M, Cranston B, Malley K and Bodner AJ . (1991). Am. J. Epidemiol., 133, 1114–1124.

  • Murphy EL, Hanchard B, Figueroa JP, Gibbs WN, Lofters WS, Campbell M and Goedert JJ . (1989b). Int. J. Cancer, 43, 250–253.

  • Murphy EL, Lee TH, Chafets D, Nass CC, Wang B, Loughlin K and Smith D . (2004a). J. Infect. Dis., 190, 504–510.

  • Murphy EL, Mahieux R, de The G, Tekaia F, Ameti D, Horton J and Gessain A . (1998). Virology, 242, 425–434.

  • Murphy EL, Wang B, Sacher RA, Fridey J, Smith JW, Nass CC, Newman B, Ownby HE, Garratty G, Hutching ST and Schreiber GB . (2004b). Emerg. Infect. Dis., 10, 109–116.

  • Murphy EL, Watanabe K, Nass CC, Ownby H, Williams A and Nemo G . (1999). J. Infect. Dis., 180, 1777–1783.

  • Murphy EL, Wilks R, Hanchard B, Cranston B, Figueroa JP, Gibbs WN, Murphy J and Blattner WA . (1996). Int. J. Epidemiol., 25, 1083–1089.

  • Nakane S, Shirabe S, Moriuchi R, Mizokami A, Furuya T, Nishiura Y, Okazaki S, Yoshizuka N, Suzuki Y, Nakamura T, Katamine S, Gojobori T and Eguchi K . (2000). J. Neurovirol., 6, 275–283.

  • Nakashima K, Kashiwagi S, Kajiyama W, Hirata M, Hayashi J, Noguchi A, Urabe K, Minami K and Maeda Y . (1995). Am J. Epidemiol., 141, 305–311.

  • Okochi K, Sato H and Hinuma Y . (1984). Vox. Sang., 46, 245–253.

  • Ono A, Ikeda E, Mochizuki M, Matsuoka M, Yamaguchi K, Sawada T, Yamane S, Tokudome S and Watanabe T . (1998). Jpn. J. Cancer Res., 89, 608–614.

  • Orland JR, Engstrom J, Fridey J, Sacher RA, Smith JW, Nass C, Garratty G, Newman B, Smith D, Wang B, Loughlin K and Murphy EL . (2003). Neurology, 61, 1588–1594.

  • Osame M, Izumo S, Igata A, Matsumoto M, Matsumoto T, Sonoda S, Tara M and Shibata Y . (1986a). Lancet, 2, 104–105.

  • Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M and Tara M . (1986b). Lancet, 1, 1031–1032.

  • Passos VMA . (1998). Cad. Saude. Publ., 14, 109–118.

  • Pawson R, Mufti GJ and Pagliuca A . (1998). Br. J. Haematol., 100, 453–458.

  • Pinheiro S . (1990). J. Acq. Immun. Def. Synd., 20, A67.

  • Pinheiro SR, Carneiro-Proietti AB, Lima-Martins MV, Proietti FA, Pereira AA and Orefice F . (1996). Rev. Soc. Bras. Med. Trop., 29, 383–384.

  • Pinheiro SR, Lana-Peixoto MA, Proietti AB, Orefice F, Lima-Martins MV and Proietti FA . (1995). Arq. Neuropsiquiatr., 53, 777–781.

  • Plancoulaine S, Gessain A, Joubert M, Tortevoye P, Jeanne I, Talarmin A, de The G and Abel L . (2000). J. Infect. Dis., 182, 405–412.

  • Poiesz BJ, Poiesz MJ and Choi D . (2003). Cancer Invest., 21, 253–277.

  • Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD and Gallo RC . (1980). Proc. Natl. Acad. Sci. USA, 77, 7415–7419.

  • Pombo-de-Oliveira MS, Carvalho SM, Borducchi D, Dobbin J, Salvador J, Correa RB, Moellman A, Loureiro P, Chiattone C and Rios M . (2001). Leuk. Lymphoma, 42, 135–144.

  • Pombo-de-Oliveira MS, Loureiro P and Bittencourt A . (1998). Int. J. Cancer, 83, 291–298.

  • Pouliquen JF, Hardy L, Lavergne A, Kafiludine E and Kazanji M . (2004). J. Clin. Microbiol., 42, 2020–2026.

  • Price J, Cant BA, Barbara JA and Tedder RS . (2001). Vox. Sang., 80, 148–150.

  • Quintas S, Moreno T, Lobo-Antunes N and Levy-Gomes A . (2004). Rev. Neurol., 39, 1133–1136.

  • Rodgers PE . (1965). West Indian Med. J., 14, 36–47.

  • Rodgers-Johnson P, Gajdusek DC, Morgan OS, Zaninovic V, Sarin PS and Graham DS . (1985). Lancet, 2, 1247–1248.

  • Roucoux DF, Wang B, Smith D, Nass CC, Smith J, Hutching ST, Newman B, Lee T-H, Chafets D and Murphy EL . (2005). J. Infectious Dis., 191, 1490–1498.

  • Sanchez-Palacios C, Gotuzzo E, Vandamme AM and Maldonado Y . (2003). Int. J. Infect. Dis., 7, 132–137.

  • Sarkodie F, Adarkwa M, Adu-Sarkodie Y, Candotti D, Acheampong JW and Allain JP . (2001). Vox. Sang., 80, 142–147.

  • Satoh M, Toma H, Sugahara K, Etoh K, Shiroma Y, Kiyuna S, Takara M, Matsuoka M, Yamaguchi K, Nakada K, Fujita K, Kojima S, Hori E, Tanaka Y, Kamihira S, Sato Y and Watanabe T . (2002). Oncogene, 21, 2466–2475.

  • Schreiber GB, Murphy EL, Horton JA, Wright DJ, Garfein R, Chien HC and Nass CC . (1997). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 14, 263–271.

  • Seiki M, Hattori S and Yoshida M . (1982). Proc. Natl. Acad. Sci. USA, 79, 6899–6902.

  • Sherman MP, Saksena NK, Dube DK, Yanagihara R and Poiesz BJ . (1992). J. Virol., 66, 2556–2563.

  • Shimamoto Y and Yamaguchi M . (1992). Leuk. Lymphoma, 7, 37–45.

  • Slattery JP, Franchini G and Gessain A . (1999). Genome Res., 9, 525–540.

  • Sonoda S . (1990). Human Retrovirology: HTLV Blattner W (ed). Raven Press: New York.

    Google Scholar 

  • Sowa JM . (1992). J. Rheumatol., 19, 316–318.

  • Stigum H, Magnus P, Samdal HH and Nord E . (2000). Int. J. Epidemiol., 29, 1076–1084.

  • Stuver SO, Tachibana N, Okayama A, Shioiri S, Tsunetoshi Y, Tsuda K and Mueller N . (1993). J. Infect. Dis., 167, 57–65.

  • Sugaya T, Ishizu A, Ikeda H, Nakamaru Y, Fugo K, Higuchi M, Yamazaki H, Imai K and Yoshiki T . (2002). Exp. Mol. Pathol., 72, 56–61.

  • Takatsuki K, Matsuoka M and Yamaguchi K . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 13 (Suppl 1), S15–S19.

  • Takatsuki K, Uchiyama T, Sagawa K and Yodoi J . (1977). Topics in Hematology Seno S, Takaku F, Irino S (eds). Excerpta Medica: Amsterdam, pp. 73–77.

    Google Scholar 

  • Takatsuki K, Yamaguchi K, Kawano F, Hattori T, Nishimura H, Tsuda H and Sanada I . (1985a). Cancer Res., 45, 4644s–4645s.

  • Takatsuki K, Yamaguchi K, Kawano F, Nishimura H, Seiki M and Yoshida M . (1985b). Microbiol. Immunol., 115, 89–97.

  • Takenouchi N, Yamano Y, Usuku K, Osame M and Izumo S . (2003). J. Neurovirol., 9, 29–35.

  • Taylor GP . (1996). J. Acq. Immun. Def. Synd. Hum. Retrovirol., 13 (Suppl 1), S8–S14.

  • Taylor GP, Bodeus M, Courtois F, Pauli G, Del Mistro A, Machuca A, Padua E, Andersson S, Goubau P, Chieco-Bianchi L, Soriano V, Coste J, Ades AE and Weber JN . (2005). J. Acq. Immun. Def. Synd., 38, 104–109.

  • Tseliou PM, Spanakis N, Spiliotakara A, Politis C, Legakis NJ and Tsakris A . (2003). Transfusion, 43, 1641–1642.

  • Uchiyama T, Yodoi J, Sagawa K, Takatsuki K and Uchino H . (1977). Blood, 50, 481–492.

  • Ureta-Vidal A, Angelin-Duclos C, Tortevoye P, Murphy E, Lepere JF, Buigues RP, Jolly N, Joubert M, Carles G, Pouliquen JF, de The G, Moreau JP and Gessain A . (1999). Int. J. Cancer, 82, 832–836.

  • Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M, Sawada T, Tsuji K, Tara M and Igata A . (1988). Ann. Neurol., 23 (Suppl), S143–S150.

  • Vandamme AM, Liu HF, Goubau P and Desmyter J . (1994). Virology, 202, 212–223.

  • Wattel E, Vartanian JP, Pannetier C and Wain-Hobson S . (1995). J. Virol., 69, 2863–2868.

  • Wilks R, Hanchard B, Morgan O, Williams E, Cranston B, Smith ML, Rodgers-Johnson P and Manns A . (1996). Int. J. Cancer, 65, 272–273.

  • Williams AE, Fang CT, Slamon DJ, Poiesz BJ, Sandler SG, Darr Jr WF, Shulman G, McGowan EI, Douglas DK, Bowman RJ, Peeetoom F, Kleinman SH, Lenes B and Dodd RY . (1988). Science, 240, 643–646.

  • Yakova M, Lezin A, Dantin F, Lagathu G, Olindo S, Jean-Baptiste G, Arfi S and Cesaire R . (2005). Retrovirology, 2, 4.

  • Yamaguchi K and Watanabe T . (2002). Int. J. Hematol., 76 (Suppl 2), 240–245.

  • Yamaguchi K . (1994). Lancet, 343, 213–216.

  • Yamaguchi K, Kiyokawa T, Futami G, Ishii T and Takatsuki K . (1990). Human Retrovirology HTLV Blattner WA (ed). Raven Press: New York, pp. 163–171.

    Google Scholar 

  • Yamamoto JH, Segurado AA, Hirata CE, Sampaio MW, Souza EC, Nukui Y, Cliquet M, Saez-Alquezar A, Olivalves E and Mochizuki M. . (1999). Arch. Ophthalmol., 117, 513–517.

  • Yanagihara R, Saitou N, Nerurkar VR, Song KJ, Bastian I, Franchini G and Gajdusek DC . (1995). Cell. Mol. Biol. (Noisy-le-grand), 41 (Suppl 1), S145–S161.

  • Yashiki S, Fujiyoshi T, Arima N, Osame M, Yoshinaga M, Nagata Y, Tara M, Nomura K, Utsunomiya A, Hanada S, Tajima K and Sonoda S . (2001). AIDS Res. Hum. Retroviruses, 17, 1047–1061.

  • Yoshida M, Seiki M, Yamaguchi K and Takatsuki K . (1984). Proc. Natl. Acad. Sci. USA, 81, 2534–2537.

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Acknowledgements

Dr Proietti, Carneiro-Proietti and Catalan-Soares are partially supported by Fundação de Amparo a Pesquisa de Minas Gerais (FAPEMIG).

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Proietti, F., Carneiro-Proietti, A., Catalan-Soares, B. et al. Global epidemiology of HTLV-I infection and associated diseases. Oncogene 24, 6058–6068 (2005). https://doi.org/10.1038/sj.onc.1208968

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