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New therapies for hepatocellular carcinoma

Oncogene volume 25, pages 3866–3884 (2006)Cite this article

Abstract

Hepatocellular carcinoma (HCC), one of the most common cancers worldwide, is often diagnosed at an advanced stage when most potentially curative therapies such as resection, transplantation or percutaneous and transarterial interventions are of limited efficacy. The fact that HCC is resistant to conventional chemotherapy, and is rarely amenable to radiotherapy, leaves this disease with no effective therapeutic options and a very poor prognosis. Therefore, the development of more effective therapeutic tools and strategies is much needed. HCCs are phenotypically and genetically heterogeneous tumors that commonly emerge on a background of chronic liver disease. However, in spite of this heterogeneity recent insights into the biology of HCC suggest that certain signaling pathways and molecular alterations are likely to play esscntial roles in HCC development by promoting cell growth and survival. The identification of such mechanisms may open new avenues for the prevention and treatment of HCC through the development of targeted therapies. In this review we will describe the new potential therapeutic targets and clinical developments that have emerged from progress in the knowledge of HCC biology, In addition, recent advances in gene therapy and combined cell and gene therapy, together with new radiotherapy techniques and immunotherapy in patients with HCC will be discussed.

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Acknowledgements

This work was supported by the agreement between FIMA and the ‘UTE project CIMA.’ This work was also supported by Grants C03/02 and G03/015 from Instituto de Salud Carlos III to MAA, CB, BS and JP, Grant SAF 2004-03538 from Ministerio de Educación y Ciencia to MAA, Grants FIS PI040819 and CP04/00123, from Ministerio de Sanidad y Consumo to CB and MAA, respectively and Grant GN Salud 23/2005 from Gobierno de Navarra to CB.

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  1. Division of Hepatology and Gene Therapy, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

    M A Avila, C Berasain, B Sangro & J Prieto

  2. Department of Medicine and Liver Unit, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain

    B Sangro & J Prieto

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  1. M A Avila
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  2. C Berasain
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Correspondence to J Prieto.

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Avila, M., Berasain, C., Sangro, B. et al. New therapies for hepatocellular carcinoma. Oncogene 25, 3866–3884 (2006). https://doi.org/10.1038/sj.onc.1209550

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