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Cross-talk between nuclear receptors and nuclear factor κB

Oncogene volume 25, pages 6868–6886 (2006)Cite this article

Abstract

A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor κB (NF-κB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-κB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-κB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.

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Abbreviations

AP-1:

activator protein-1

AR:

androgen receptor

Brg1:

brahma-related gene 1

BTM:

basal transcription machinery

CARM:

coactivator-associated arginine methyltransferase

COX:

cyclooxygenase

DBD:

DNA-binding domain

DRIP:

vitamin D receptor-interacting protein

ER:

estrogen receptor

FRAP:

fluorescence recovery after photobleaching

GILZ:

glucocorticoid-induced leucine zipper

GR:

glucocorticoid receptor

GRIP:

glucocorticoid receptor-interacting protein

(n)GRE:

(negative) glucocorticoid response element

HAT:

histone acetyltransferase

HDAC:

histone deacetylase

Hsp:

heat shock protein

IκB:

inhibitor κB

IKK:

IκB kinase

IL:

interleukin

iNOS:

inducible nitric oxide synthase

LBD:

ligand-binding domain

LSD1:

lysine-specific histone demethylase 1

LXR:

liver X receptor

MAPK:

mitogen-actived protein kinase

MKP-1:

mitogen-activated protein kinase phosphatase 1

MMP:

matrix metalloproteinase

MR:

mineralocorticoid receptor

MTA:

metastasis-associated protein

NcoR:

nuclear corepressor

NF-κB:

nuclear factor κB

NR:

nuclear receptor

PGC-1:

PPARγ coactivator-1

PPAR:

peroxisome proliferator-activated receptor

PK:

protein kinase

PLA:

phospholipase A

PR:

progesterone receptor

PSA:

prostate-specific antigen

p-TEFb:

transcription elongation factor

pol:

polymerase

RAR/RXR:

retinoid acid receptor/retinoid X receptor

SEGRM:

selective GR modulators

SERM:

selective ER modulators

SMRT:

silencing mediator of retinoic-acid and thyroid hormone receptors

SRC-1:

steroid receptor coactivator-1

TBL1:

transducin-β-like 1

TF:

transcription factor

TIF:

transcription intermediary factor

TLR:

toll-like receptor

TNF:

tumor necrosis factor

TR:

thyroid hormone receptor

TRAP:

thyroid receptor-activated protein

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Acknowledgements

We thank the University of Gent, the IAP and Marató programs, and the FWO-Vlaanderen for financial support. KDB and WVB are postdoctoral fellows with the FWO-Vlaanderen.

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  1. Department of Molecular Biology, Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Ghent University, Gent, Belgium

    K De Bosscher, W Vanden Berghe & G Haegeman

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De Bosscher, K., Vanden Berghe, W. & Haegeman, G. Cross-talk between nuclear receptors and nuclear factor κB. Oncogene 25, 6868–6886 (2006). https://doi.org/10.1038/sj.onc.1209935

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