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Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

Oncogene volume 25, pages 6781–6799 (2006)Cite this article

Abstract

The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-κB pathway, namely the IκB kinase subunits (IKKα, IKKβ and NEMO), the IκB proteins (IκBα, IκBβ, IκBɛ and Bcl-3) and the five NF-κB transcription factors (NF-κB1, NF-κB2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knockout technology.

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References

  • Alcamo E, Hacohen N, Schulte LC, Rennert PD, Hynes RO, Baltimore D . (2002). J Exp Med 195: 233–244.

  • Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M et al. (2001). J Immunol 16: 1592–1600.

  • Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS . (2003). Nature 423: 659–663.

  • Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM et al. (2005). Nat Med 11: 191–198.

  • Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR et al. (1999). J Immunol 163: 5116–5124.

  • Artis D, Kane CM, Fiore J, Zaph C, Shapira S, Joyce K et al. (2005). J Immunol 174: 7154–7159.

  • Artis D, Speirs K, Joyce K, Goldschmidt M, Caamano J, Hunter CA et al. (2003). J Immunol 170: 1995–2003.

  • Attar RM, Macdonald-Bravo H, Raventos-Suarez C, Durham SK, Bravo R . (1998). Mol Cell Biol 18: 477–487.

  • Aune TM, Mora AL, Kim S, Boothby M, Lichtman AH . (1999). J Immunol 162: 5805–5812.

  • Baldwin Jr AS . (2006). Oncogene 25: 6817–6830.

  • Banerjee A, Gugasyan R, McMahon M, Gerondakis S . (2006). Proc Natl Acad Sci USA 103: 3274–3279.

  • Banerjee D, Liou H-C, Sen R . (2005). Immunity 23: 445–458.

  • Beg AA, Baltimore D . (1996). Science 274: 782–784.

  • Beg AA, Sha WC, Bronson RT, Baltimore D . (1995a). Genes Dev 9: 2736–2746.

  • Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D . (1995b). Nature 376: 167–170.

  • Beinke S, Ley SC . (2004). Biochem J 382: 393–409.

  • Bendall HH, Sikes ML, Ballard DW, Oltz EM . (1999). Mol Immunol 36: 187–195.

  • Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D et al. (2004). EMBO J 23: 4202–4210.

  • Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW . (1997). J Exp Med 185: 1897–1907.

  • Burkly L, Hession C, Ogata L, Reilly C, Marconi LA, Olson D et al. (1995). Nature 373: 531–536.

  • Caamano J, Alexander J, Craig L, Bravo R, Hunter CA . (1999). J Immunol 163: 4453–4461.

  • Caamano J, Tato C, Cai G, Villegas EN, Speirs K, Craig L et al. (2000). J Immunol 165: 5720–5728.

  • Caamano JH, Rizzo CA, Durham SK, Barton DS, Raventos-Suarez C, Snapper CM et al. (1998). J Exp Med 187: 185–196.

  • Cai D, Frantz JD, Tawa Jr NE, Melendez PA, Oh BC, Lidov HG et al. (2004). Cell 119: 285–298.

  • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J et al. (2005). Nat Med 11: 183–190.

  • Campbell IK, Gerondakis S, O'Donnell K, Wicks IP . (2000). J Clin Invest 105: 1799–1806.

  • Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV et al. (2001). Cell 107: 763–775.

  • Cariappa A, Liou H-C, Horwitz BH, Pillai S . (2000). J Exp Med 192: 1175–1182.

  • Carlsen H, Moskaug JO, Fromm SH, Blomhoff R . (2002). J Immunol 168: 1441–1446.

  • Carrasco D, Cheng J, Lewin A, Warr G, Yang H, Rizzo C et al. (1998). J Exp Med 187: 973–984.

  • Carrasco D, Perez P, Lewin A, Bravo R . (1997). J Exp Med 186: 279–288.

  • Carrasco D, Rizzo CA, Dorfman K, Bravo R . (1996). EMBO J 15: 3640–3650.

  • Castiglioni P, Janssen EM, Prilliman KR, Gerloni M, Schoenberger S, Zanetti M . (2002). Scand J Immunol 56: 219–223.

  • Chaisson ML, Brooling JT, Ladiges W, Tsai Sand Fausto N . (2002). J Clin Invest 110: 193–202.

  • Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD . (2000). J Immunol 165: 5418–5427.

  • Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M . (2003). Nat Med 9: 575–581.

  • Chen X, Wang J, Woltring D, Gerondakis S, Shannon MF . (2005). Mol Cell Biol 25: 3209–3219.

  • Cheng JD, Ryseck RP, Attar RM, Dambach D, Bravo R . (1998). J Exp Med 188: 1055–1062.

  • Cheng S, Hsia CY, Leone G, Liou H-C . (2003). Oncogene 22: 8472–8486.

  • Claudio E, Brown K, Park S, Wang H, Siebenlist U . (2002). Nat Immunol 3: 958–965.

  • Corn RA, Aronica MA, Zhang F, Tong Y, Stanley SA, Kim SR et al. (2003). J Immunol 171: 1816–1824.

  • Corn RA, Hunter C, Liou H-C, Siebenlist U, Boothby MR . (2005). J Immunol 175: 2102–2110.

  • Courtois G, Gilmore TD . (2006). Oncogene 25: 6831–6843.

  • Das J, Chen CH, Yang L, Cohn L, Ray P, Ray A . (2001). Nat Immunol 2: 45–50.

  • Dawn B, Xuan YT, Marian M, Flaherty MP, Murphree SS, Smith TL et al. (2001). J Mol Cell Cardiol 33: 161–173.

  • Doi TS, Marino MW, Takahashi T, Yoshida T, Sakakura T, Old LJ et al. (1999). Proc Natl Acad Sci USA 196: 2994–2999.

  • Elewaut D, Shaikh RB, Hammond KJ, De Winter H, Leishman AJ, Sidobre S et al. (2003). J Exp Med 197: 1623–1633.

  • Esslinger CW, Wilson A, Sordat B, Beermann F, Jongeneel CV . (1997). J Immunol 158: 5075–5078.

  • Ferreira V, Sidenius N, Tarantino N, Hubert P, Chatenoud L, Blasi F et al. (1999). J Immunol 162: 6442–6450.

  • Finn PW, Stone JR, Boothby MR, Perkins DL . (2001). J Immunol 167: 5994–6001.

  • Franzoso G, Carlson L, Poljak L, Shores EW, Epstein S, Leonardi A et al. (1998). J Exp Med 187: 147–159.

  • Franzoso G, Carlson L, Scharton-Kersten T, Shores EW, Epstein S, Grinberg A et al. (1997a). Immunity 6: 479–490.

  • Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD et al. (1997b). Genes Dev 11: 3482–3496.

  • Fridmacher V, Kaltschmidt B, Goudeau B, Ndiaye D, Rossi FM, Pfeiffer J et al. (2003). J Neurosci 23: 9403–9408.

  • Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB et al. (2004). J Immunol 173: 5786–5793.

  • Gélinas C . (2006). Oncogene 25: 6800–6816.

  • Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R . (1999). Oncogene 18: 6888–6895.

  • Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck JY, Grumont RJ . (1996). Proc Natl Acad Sci USA 93: 3405–3409.

  • Gerondakis S, Strasser S . (2003). Semin Immunol 15: 159–166.

  • Gilmore TD . (2006). Oncogene 25: 6680–6684.

  • Gilmore TD, Kalaitzidis D, Liang M-C, Starczynowski DT . (2004). Oncogene 23: 2275–2286.

  • Goudeau B, Huetz F, Samson S, Di Santo JP, Cumano A, Beg A et al. (2003). Proc Natl Acad Sci USA 100: 15800–15805.

  • Graham B, Gibson SB . (2005). Cell Cycle 4: 1342–1345.

  • Grigoriadis G, Zhan Y, Grumont RJ, Metcalf D, Handman E, Cheers C et al. (1996). EMBO J 16: 7099–7107.

  • Grossmann M, O'Reilly LA, Gugasyan R, Strasser A, Adams JM, Gerondakis S . (2000). EMBO J 19: 6351–6360.

  • Grossmann M, Metcalf D, Merryfull J, Beg A, Baltimore D, Gerondakis S . (1999). Proc Natl Acad Sci USA 96: 11848–11853.

  • Grumont R, Hochrein H, O'Keeffe M, Gugasyan R, White C, Caminschi I et al. (2001). J Exp Med 194: 1021–1032.

  • Grumont R, Lock P, Mollinari M, Shannon FM, Moore A, Gerondakis S . (2004). Immunity 21: 19–30.

  • Grumont RJ, Rourke IJ, Gerondakis S . (1999). Genes Dev 13: 400–411.

  • Grumont RJ, Rourke IJ, O'Reilly LA, Strasser A, Miyake K, Sha W et al. (1998). J Exp Med 187: 663–677.

  • Grumont RJ, Strasser A, Gerondakis S . (2002). Mol Cell 10: 1283–1294.

  • Guerin S, Baron ML, Valero R, Herrant M, Auberger P, Naquet P . (2002). Eur J Immunol 32: 1–9.

  • Gugasyan R, Voss A, Varigos G, Thomas T, Grumont RJ, Kaur P et al. (2004). Mol Cell Biol 24: 5733–5745.

  • Hatada EN, Do RK, Orlofsky A, Liou H-C, Prystowsky M, MacLennan IC et al. (2003). J Immunol 171: 761–768.

  • Hayden MS, Ghosh S . (2004). Genes Dev 18: 2195–2224.

  • Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, Kleesiek J et al. (2005). Nat Med 11: 1322–1329.

  • Hettmann T, DiDonato J, Karin M, Leiden JM . (1999). J Exp Med 189: 145–158.

  • Hettmann T, Leiden JM . (2000). J Immunol 165: 5004–5010.

  • Hilliard BA, Mason N, Xu L, Sun J, Lamhamedi-Cherradi SE, Liou H-C et al. (2002). J Clin Invest 110: 843–850.

  • Hoffmann A, Levchenko A, Scott ML, Baltimore D . (2002). Science 298: 1189–1190.

  • Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D . (1997). Immunity 6: 765–772.

  • Horwitz BH, Zelazowski P, Shen Y, Wolcott KM, Scott ML, Baltimore D et al. (1999). J Immunol 162: 1941–1946.

  • Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M et al. (1999). Science 284: 316–320.

  • Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M . (2001). Nature 410: 710–714.

  • Hunter RB, Kandarian SC . (2004). J Clin Invest 114: 1504–1511.

  • Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW et al. (1998). J Clin Invest 101: 802–811.

  • Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R . (1997). Nat Med 3: 1285–1289.

  • Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N et al. (2001). J Exp Med 193: 417–426.

  • Kanters E, Gijbels MJJ, van der Made I, Vergouwe MN, Heeringa P, Kraal G et al. (2004). Blood 103: 934–940.

  • Karin M, Delhase M . (2000). Semin Immunol 12: 85–98.

  • Karin M, Lin A . (2002). Nat Immunol 3: 221–227.

  • Kaltschmidt B, Ndiaye D, Korte M, Pothion S, Arbibe L, Prullage M et al. (2006). Mol Cell Biol 26: 2936–2946.

  • Klement JF, Rice NR, Car BD, Abbondanzo SJ, Powers GD, Bhatt PH et al. (1996). Mol Cell Biol 16: 2341–2349.

  • Ishikawa H, Carrasco D, Claudio E, Ryseck RP, Bravo R . (1997). J Exp Med 186: 999–1014.

  • Ishikawa H, Claudio E, Dambach D, Raventos-Suarez C, Ryan C, Bravo R . (1998). J Exp Med 187: 985–996.

  • Köntgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D et al. (1995). Genes Dev 9: 1965–1977.

  • Kim S, La Motte-Mohs RN, Rudolph D, Zuniga-Pflucker JC, Mak TW . (2003). Proc Natl Acad Sci USA 100: 1203–1208.

  • Lamhamedi-Cherradi SE, Zheng S, Hilliard BA, Xu L, Sun J, Alsheadat S et al. (2003). J Immunol 171: 4886–4892.

  • Lavon I, Goldberg I, Amit S, Landsman L, Jung S, Tsuberi BZ et al. (2000). Nat Med 6: 573–577.

  • Lawrence T, Bebien M, Liu GY, Nizet V, Karin M . (2005). Nature 434: 1138–1143.

  • Lernbecher T, Muller U, Wirth T . (1993). Nature 365: 767–770.

  • Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC et al. (2004). J Neurosci 24: 3933–3943.

  • Li M, Shillinglaw W, Henzel WJ, Beg AA . (2001). J Biol Chem 276: 1185–1194.

  • Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F et al. (2005). Proc Natl Acad Sci USA 102: 12425–12430.

  • Li Q, Lu Q, Hwang JY, Buscher D, Lee KF, Izpisua-Belmonte JC et al. (1999a). Genes Dev 13: 1322–1328.

  • Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM . (1999b). Science 284: 321–325.

  • Li Q, Verma IM . (2002). Nat Rev Immunol 2: 725–734.

  • Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M et al. (1999). J Exp Med 189: 1839–1845.

  • Li ZW, Omori SA, Labuda T, Karin M, Rickert RC . (2003). J Immunol 170: 4630–4637.

  • Lind MH, Rozell B, Wallin RP, van Hogerlinden M, Ljunggren HG, Toftgård R et al. (2004). Proc Natl Acad Sci USA 101: 4972–4977.

  • Liou H-C, Hsia CY . (2003). BioEssays 25: 767–780.

  • Lo JC, Basak S, James ES, Quiambo RS, Kinsella MC, Alegre ML et al. (2006). Blood 107: 1048–1055.

  • Luedde T, Assmus U, Wustefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M et al. (2005). J Clin Invest 115: 849–859.

  • Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M . (2003). Immunity 19: 725–737.

  • Maeda S, Kamata H, Luo JL, Leffert H, Karin M . (2005). Cell 121: 977–990.

  • Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner DA, Jobin C . (2004). J Immunol 173: 1561–1570.

  • Makris C, Godfrey VL, Krahn-Senftleben G, Takahashi T, Roberts JL, Schwarz T et al. (2000). Mol Cell 5: 969–979.

  • Mason NJ, Liou H-C, Hunter CA . (2004). J Immunol 172: 3704–3711.

  • Meffert MK, Baltimore D . (2005). Trends Neurosci 28: 37–43.

  • Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D . (2003). Nat Neurosci 6: 1072–1080.

  • Memet S, Laouini D, Epinat JC, Whiteside ST, Goudeau B, Philpott D et al. (1999). J Immunol 163: 5994–6005.

  • Mintern JD, Belz G, Gerondakis S, Carbone FR, Heath WR . (2002). J Immunol 168: 3283–3287.

  • Mora AL, Corn RA, Stanic AK, Goenka S, Aronica M, Stanley S et al. (2003). Cell Death Differ 10: 1032–1044.

  • Norlin S, Ahlgren U, Edlund H . (2005). Diabetes 54: 125–132.

  • O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM et al. (2005). J Clin Invest 115: 2341–2350.

  • O'Keeffe M, Grumont RJ, Hochrein H, Fuchsberger M, Gugasyan R, Vremec D et al. (2005). Blood 106: 3457–3464.

  • Ong ST, Hackbarth ML, Degenstein LC, Baunoch DA, Anastasi J, McKeithan TW . (1998). Oncogene 16: 2333–2343.

  • Ouaaz F, Arron J, Zheng Y, Choi Y, Beg AA . (2002). Immunity 16: 257–270.

  • Pahl HL . (1999). Oncogene 18: 6853–6866.

  • Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K et al. (2005). Immunity 23: 319–329.

  • Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A et al. (2002a). Nature 417: 861–866.

  • Pasparakis M, Schmidt-Supprian M, Rajewsky K . (2002b). J Exp Med 196: 743–752.

  • Perkins ND . (2006). Oncogene 25: 6717–6730.

  • Pizzi M, Goffi F, Boroni F, Benarese M, Perkins SE, Liou H-C et al. (2002). J Biol Chem 277: 20717–20723.

  • Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G et al. (2005). Cell Death Differ 12: 761–772.

  • Pohl T, Gugasyan R, Grumont RJ, Strasser A, Metcalf D, Tarlinton D et al. (2002). Proc Natl Acad Sci USA 99: 4514–4519.

  • Prendes M, Zheng Y, Beg AA . (2003). J Immunol 171: 3963–3969.

  • Rao S, Gerondakis S, Woltring D, Shannon MF . (2003). J Immunol 170: 3724–3731.

  • Romieu-Mourez R, Kim DW, Shin SM, Demicco EG, Landesman-Bollag E, Seldin DC et al. (2003). Mol Cell Biol 23: 5738–5754.

  • Rudolph D, Yeh WC, Wakeham A, Rudolph B, Nallainathan D, Potter J et al. (2000). Genes Dev 14: 854–862.

  • Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y et al. (2005). J Exp Med 201: 1677–1687.

  • Rupec RA, Jundt F, Rebholz B, Eckelt B, Weindl G, Herzinger T et al. (2005). Immunity 22: 479–491.

  • Samson SI, Memet S, Vosshenrich CA, Colucci F, Richard O, Ndiaye D et al. (2004). Blood 103: 4573–4580.

  • Sanjabi S, Hoffmann A, Liou H-C, Baltimore D, Smale ST . (2000). Proc Natl Acad Sci USA 97: 12705–12710.

  • Scheidereit C . (2006). Oncogene 25: 6685–6705.

  • Schmidt-Supprian M, Bloch W, Courtois G, Addicks K, Israël A, Rajewsky K et al. (2000). Mol Cell 5: 981–992.

  • Schmidt-Supprian M, Courtois G, Tian J, Coyle AJ, Israël A, Rajewsky K et al. (2003). Immunity 19: 377–389.

  • Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H et al. (2004). Proc Natl Acad Sci USA 101: 4566–4571.

  • Schmidt-Ullrich R, Aebischer T, Hulsken J, Birchmeier W, Klemm U, Scheidereit C . (2001). Development 128: 3843–3853.

  • Schmidt-Ullrich R, Memet S, Lilienbaum A, Feuillard J, Raphael M, Israël A . (1996). Development 122: 2117–2128.

  • Schwabe RF, Brenner DA . (2006). Am J Physiol Gastrointest Liver Physiol 290: 583–589.

  • Schwarz EM, Krimpenfort P, Berns A, Verma IM . (1997). Genes Dev 11: 187–197.

  • Seitz CS, Lin Q, Deng H, Khavari PA . (1998). Proc Natl Acad Sci USA 95: 2307–2312.

  • Senftleben U, Li ZW, Baud V, Karin M . (2001). Immunity 14: 217–230.

  • Sha WC, Liou H-C, Tuomanen EI, Baltimore D . (1995). Cell 80: 321–330.

  • Sil AK, Maeda S, Sano Y, Roop DR, Karin M . (2004). Nature 428: 660–664.

  • Sivakumar V, Hammond KJ, Howells N, Pfeffer K, Weih F . (2003). J Exp Med 197: 1613–1621.

  • Snapper CM, Zelazowski P, Rosas FR, Kehry MR, Tian M, Baltimore D et al. (1996). J Immunol 156: 183–191.

  • Speirs K, Caamano J, Goldschmidt MH, Hunter CA, Scott P . (2002). J Immunol 168: 4406–4413.

  • Speirs K, Lieberman L, Caamano J, Hunter CA, Scott P . (2004). J Immunol 172: 752–756.

  • Strasser A, Grumont RJ, Stanley ML, Gerondakis S . (1999). Eur J Immunol 29: 928–935.

  • Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T et al. (1999). Science 284: 313–316.

  • Tanaka M, Fuentes ME, Yamaguchi K, Durnin MH, Dalrymple SA, Hardy KL et al. (1999). Immunity 10: 421–429.

  • Tato CM, Mason N, Artis D, Shapira S, Caamano JC, Bream JH et al. (2006). Int Immunol 18: 505–513.

  • Tato CM, Villarino A, Caamano JH, Boothby M, Hunter CA . (2003). J Immunol 170: 3139–3146.

  • Thomas R . (2005). Arthritis Res Ther 7: 170–173.

  • van Hogerlinden M, Rozell BL, hrlund-Richter L, Toftgård R . (1999). Cancer Res 59: 3299–3303.

  • Voll RE, Jimi E, Phillips RJ, Barber DF, Rincon M, Hayday AC et al. (2000). Immunity 13: 677–689.

  • Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS et al. (2004). Cancer Res 64: 6240–6246.

  • Waterfield MR, Zhang M, Norman LP, Sun S-C . (2003). Mol Cell 11: 685–694.

  • Weih DS, Yilmaz ZB, Weih F . (2001). J Immunol 167: 1909–1919.

  • Weih F, Caamano J . (2003). Immunol Rev 195: 91–105.

  • Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck R-P et al. (1995). Cell 80: 331–340.

  • Weih F, Durham SK, Barton DS, Sha WC, Baltimore D, Bravo R . (1997). J Exp Med 185: 1359–1370.

  • Wu L, D'Amico A, Winkel KD, Suter M, Lo D, Shortman K . (1998). Immunity 9: 839–947.

  • Yamada Y, Kirillova I, Peschon JJ, Fausto N . (1997). Proc Natl Acad Sci USA 94: 1441–1446.

  • Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB . (2003). Nature 423: 655–659.

  • Yan M, Brady JR, Chan B, Lee WP, Hsu B, Harless S et al. (2001). Curr Biol 11: 1547–1552.

  • Yang H, Thomas D, Boffa DJ, Ding R, Li B, Muthukumar T et al. (2002). Transplantation 74: 291–298.

  • Yilmaz ZB, Weih DS, Sivakumar V, Weih F . (2003). EMBO J 22: 121–130.

  • Xing L, Bushnell TP, Carlson L, Tai Z, Tondravi M, Siebenlist U et al. (2002). J Bone Miner Res 17: 1200–1210.

  • Zanetti M, Castiglioni P, Schoenberger S, Gerloni M . (2003). Ann NY Acad Sci 987: 249–257.

  • Zhang JY, Green CL, Tao S, Khavari PA . (2004). Genes Dev 18: 17–22.

  • Zheng Y, Vig M, Lyons J, Van Parijs L, Beg AA . (2003). J Exp Med 197: 861–874.

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Acknowledgements

Owing to the extensive and overlapping nature of the literature encompassing this subject matter, it is inevitable that certain studies were not quoted and the authors apologize to colleagues for any such omissions. We also wish to acknowledge the ongoing support that the laboratory receives from the National Health and Medical Research Council (Australia) and the Leukaemia and Lymphoma Society (USA).

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  1. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

    S Gerondakis, R Grumont, R Gugasyan, L Wong, I Isomura, W Ho & A Banerjee

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Gerondakis, S., Grumont, R., Gugasyan, R. et al. Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models. Oncogene 25, 6781–6799 (2006). https://doi.org/10.1038/sj.onc.1209944

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