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A role of estrogen/ERα signaling in BRCA1-associated tissue-specific tumor formation

Oncogene volume 26, pages 7204–7212 (2007)Cite this article

Abstract

Estrogen and its receptor alpha (ERα) have been implicated in the tissue-specific tumorigenesis associated with BRCA1 mutations. However, the majority of breast cancers developed in human BRCA1 mutation carriers are ERα-negative, challenging the link between BRCA1 and estrogen/ERα in breast cancer formation. Using a mouse model lacking the full-length form of BRCA1, here we show that ERα is highly expressed in the premalignant mammary gland and initiation stages of tumorigenesis, although its expression is gradually diminished during mammary tumor progression. We demonstrate that the absence of full-length BRCA1 increases sensitivity of cells to estrogen-induced extracellular signal-regulated kinase 1/2 phosphorylation and cyclin D1 expression. The absence of BRCA1 turns the proliferation of ERα-positive cells from a paracrine fashion to an autocrine or endocrine fashion. Consequently, BRCA1-mutant cells are sensitized to estrogen-induced cell proliferation in vitro and mammary tumorigenesis in vivo. These findings illustrate a molecular mechanism for estrogen/ERα signals in BRCA1-associated tissue-specific tumor formation, and identify several key elements in the estrogen/ERα-signaling cascade that can serve as potential therapeutic targets for BRCA1-associated tumorigenesis.

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Acknowledgements

We thank Thomas Fishler, Yohei Tominaga and Rui-Hong Wang for critical reading of this paper. This research was supported by the Intramural Research Program of the National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, USA.

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Authors and Affiliations

  1. Genetics of Development and Disease Branch, 10/9N105, NIDDK, National Institutes of Health, Bethesda, MD, USA

    W Li, C Xiao & C-X Deng

  2. Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    B K Vonderhaar

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  1. W Li
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  2. C Xiao
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  3. B K Vonderhaar
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  4. C-X Deng
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Correspondence to C-X Deng.

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Li, W., Xiao, C., Vonderhaar, B. et al. A role of estrogen/ERα signaling in BRCA1-associated tissue-specific tumor formation. Oncogene 26, 7204–7212 (2007). https://doi.org/10.1038/sj.onc.1210527

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