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MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

Abstract

Genes of the human monocytic leukemia zinc-finger protein MOZ (HUGO symbol, MYST3) and its paralog MORF (MYST4) are rearranged in chromosome translocations associated with acute myeloid leukemia and/or benign uterine leiomyomata. Both proteins have intrinsic histone acetyltransferase activity and are components of quartet complexes with noncatalytic subunits containing the bromodomain, plant homeodomain-linked (PHD) finger and proline-tryptophan-tryptophan-proline (PWWP)-containing domain, three types of structural modules characteristic of chromatin regulators. Although leukemia-derived fusion proteins such as MOZ-TIF2 promote self-renewal of leukemic stem cells, recent studies indicate that murine MOZ and MORF are important for proper development of hematopoietic and neurogenic progenitors, respectively, thereby highlighting the importance of epigenetic integrity in safeguarding stem cell identity.

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References

  • Antonchuk J, Hyland CD, Hilton DJ, Alexander WS . (2004). Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 104: 1306–1313.

    CAS  PubMed  Google Scholar 

  • Avvakumov N, Côté J . (2007). Histone acetyltransferases of the MYST family and their roles in cancer. Oncogene 26: 5395–5407.

    CAS  PubMed  Google Scholar 

  • Baylin SB, Herman JG . (2000). DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16: 168–174.

    CAS  PubMed  Google Scholar 

  • Berger SL . (2002). Histone modifications in transcriptional regulation. Curr Opin Genet Dev 12: 142–148.

    CAS  PubMed  Google Scholar 

  • Borrow J, Stanton Jr VP, Andresen JM, Becher R, Behm FG, Chaganti RS et al. (1996). The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet 14: 33–41.

    CAS  PubMed  Google Scholar 

  • Boudreault AA, Cronier D, Selleck W, Lacoste N, Utley RT, Allard S et al. (2003). Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev 17: 1415–1428.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP et al. (2005). Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122: 947–956.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bristow CA, Shore P . (2003). Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ. Nucleic Acids Res 31: 2735–2744.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Camos M, Esteve J, Jares P, Colomer D, Rozman M, Villamor N et al. (2006). Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression. Cancer Res 66: 6947–6954.

    CAS  PubMed  Google Scholar 

  • Carapeti M, Aguiar RC, Goldman JM, Cross NC . (1998). A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. Blood 91: 3127–3133.

    CAS  PubMed  Google Scholar 

  • Carrozza MJ, Utley RT, Workman JL, Côté J . (2003). The diverse functions of histone acetyltransferase complexes. Trends Genet 19: 321–329.

    CAS  PubMed  Google Scholar 

  • Ceol CJ, Horvitz HR . (2004). A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev Cell 6: 563–576.

    CAS  PubMed  Google Scholar 

  • Chaffanet M, Gressin L, Preudhomme C, Soenen-Cornu V, Birnbaum D, Pebusque MJ . (2000). MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). Genes Chromosomes Cancer 28: 138–144.

    CAS  PubMed  Google Scholar 

  • Chamberlin HM, Thomas JH . (2000). The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans. Development 127: 713–723.

    CAS  PubMed  Google Scholar 

  • Champagne N, Bertos NR, Pelletier N, Wang AH, Vezmar M, Yang Y et al. (1999). Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. J Biol Chem 274: 28528–28536.

    CAS  PubMed  Google Scholar 

  • Champagne N, Pelletier N, Yang XJ . (2001). The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase. Oncogene 20: 404–409.

    CAS  PubMed  Google Scholar 

  • Chang S, Johnston Jr RJ, Hobert O . (2003). A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans. Genes Dev 17: 2123–2137.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Collins HM, Kindle KB, Matsuda S, Ryan C, Troke PJ, Kalkhoven E et al. (2006). MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators. J Biol Chem 281: 17124–17133.

    CAS  PubMed  Google Scholar 

  • Crump JG, Swartz ME, Eberhart JK, Kimmel CB . (2006). Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development 133: 2661–2669.

    CAS  PubMed  Google Scholar 

  • Deguchi K, Ayton PM, Carapeti M, Kutok JL, Snyder CS, Williams IR et al. (2003). MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 3: 259–271.

    CAS  PubMed  Google Scholar 

  • Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J et al. (2005). Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121: 873–885.

    CAS  PubMed  Google Scholar 

  • Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W et al. (2006). ING tumor suppressors are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell 21: 51–64.

    CAS  PubMed  Google Scholar 

  • Doyon Y, Côté J . (2004). The highly conserved and multifunctional NuA4 HAT complex. Curr Opin Genet Dev 14: 147–154.

    CAS  PubMed  Google Scholar 

  • Doyon Y, Selleck W, Lane WS, Tan S, Côté J . (2004). Structural and functional conservation of the NUA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol 24: 1884–1896.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Egger G, Liang G, Aparicio A, Jones PA . (2004). Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457–463.

    CAS  PubMed  Google Scholar 

  • Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G et al. (2005). Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37: 391–400.

    CAS  PubMed  Google Scholar 

  • Gong W, Suzuki K, Russell M, Riabowol K . (2005). Function of the ING family of PHD proteins in cancer. Int J Biochem Cell Biol 37: 1054–1065.

    CAS  PubMed  Google Scholar 

  • Goodman RH, Smolik S . (2000). CBP/p300 in cell growth, transformation, and development. Genes Dev 14: 1553–1577.

    CAS  PubMed  Google Scholar 

  • Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA et al. (2003). The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 114: 99–111.

    CAS  PubMed  Google Scholar 

  • Grier DG, Thompson A, Kwasniewska A, McGonigle GJ, Halliday HL, Lappin TR . (2005). The pathophysiology of HOX genes and their role in cancer. J Pathol 205: 154–171.

    CAS  PubMed  Google Scholar 

  • Hilfiker A, Hilfiker-Kleiner D, Pannuti A, Lucchesi JC . (1997). MOF, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J 16: 2054–2060.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Horn PJ, Peterson CL . (2002). Chromatin higher order folding – wrapping up transcription. Science 297: 1824–1827.

    CAS  PubMed  Google Scholar 

  • Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N et al. (2004). MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 6: 587–596.

    CAS  PubMed  Google Scholar 

  • Iizuka M, Stillman B . (1999). Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. J Biol Chem 274: 23027–23034.

    CAS  PubMed  Google Scholar 

  • Ito Y . (2004). Oncogenic potential of the RUNX gene family: ‘overview’. Oncogene 23: 4198–4208.

    CAS  PubMed  Google Scholar 

  • Jaenisch R, Bird A . (2003). Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 (Suppl): 245–254.

    CAS  PubMed  Google Scholar 

  • Jason LJ, Moore SC, Lewis JD, Lindsey G, Ausio J . (2002). Histone ubiquitination: a tagging tail unfolds? Bioessays 24: 166–174.

    CAS  PubMed  Google Scholar 

  • Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G . (1996). Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216: 357–366.

    CAS  PubMed  Google Scholar 

  • Katsumoto T, Aikawa Y, Iwama A, Ueda S, Ichikawa H, Ochiya T et al. (2006). MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev 20: 1321–1330.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Khorasanizadeh S . (2004). The nucleosome: from genomic organization to genomic regulation. Cell 116: 259–272.

    CAS  PubMed  Google Scholar 

  • Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J et al. (2006). Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 23: 607–618.

    CAS  PubMed  Google Scholar 

  • Kindle KB, Troke PJ, Collins HM, Matsuda S, Bossi D, Bellodi C et al. (2005). MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol 25: 988–1002.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kirito K, Fox N, Kaushansky K . (2004). Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Mol Cell Biol 24: 6751–6762.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kitabayashi I, Aikawa Y, Nguyen LA, Yokoyama A, Ohki M . (2001a). Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. EMBO J 20: 7184–7196.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kitabayashi I, Aikawa Y, Yokoyama A, Hosoda F, Nagai M, Kakazu N et al. (2001b). Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. Leukemia 15: 89–94.

    CAS  PubMed  Google Scholar 

  • Kojima K, Kaneda K, Yoshida C, Dansako H, Fujii N, Yano T et al. (2003). A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13). Br J Haematol 120: 271–273.

    CAS  PubMed  Google Scholar 

  • Kouzarides T . (2007). Chromatin modifications and their function. Cell 128: 693–705.

    CAS  PubMed  Google Scholar 

  • Kusch T, Florens L, Macdonald WH, Swanson SK, Glaser RL, Yates III JR et al. (2004). Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306: 2084–2087.

    CAS  PubMed  Google Scholar 

  • Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D . (2002). Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol 22: 835–848.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lafon A, Chang CS, Scott EM, Jacobson SJ, Pillus L . (2007). MYST opportunities for growth control: yeast genes illuminate human cancer gene functions. Oncogene 26: 5373–5384.

    CAS  PubMed  Google Scholar 

  • Lee KK, Workman JL . (2007). Histone acetyltransferase complexes: one size doesn't fit all. Nat Rev Mol Cell Biol 8: 284–295.

    CAS  PubMed  Google Scholar 

  • Leo C, Chen JD . (2000). The SRC family of nuclear receptor coactivators. Gene 245: 1–11.

    CAS  PubMed  Google Scholar 

  • Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S et al. (1998). Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci USA 95: 11590–11595.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li B, Carey M, Workman JL . (2007). The role of chromatin during transcription. Cell 128: 707–719.

    CAS  PubMed  Google Scholar 

  • Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD et al. (2006). Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 442: 91–95.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Liang J, Prouty L, Williams BJ, Dayton MA, Blanchard KL . (1998). Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2. Blood 92: 2118–2122.

    CAS  PubMed  Google Scholar 

  • Loewith R, Meijer M, Lees-Miller SP, Riabowol K, Young D . (2000). Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol 20: 3807–3816.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Loewith R, Smith JS, Meijer M, Williams TJ, Bachman N, Boeke JD et al. (2001). Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. J Biol Chem 276: 24068–24074.

    CAS  PubMed  Google Scholar 

  • Martin DG, Grimes DE, Baetz K, Howe L . (2006). Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin. Mol Cell Biol 26: 3018–3028.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maurer-Stroh S, Dickens NJ, Hughes-Davies L, Kouzarides T, Eisenhaber F, Ponting CP . (2003). The Tudor domain ‘Royal Family’: Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci 28: 69–74.

    CAS  PubMed  Google Scholar 

  • Mendjan S, Taipale M, Kind J, Holz H, Gebhardt P, Schelder M et al. (2006). Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell 21: 811–823.

    CAS  PubMed  Google Scholar 

  • Merson TD, Dixon MP, Collin C, Rietze RL, Bartlett PF, Thomas T et al. (2006). The transcriptional coactivator Querkopf controls adult neurogenesis. J Neurosci 26: 11359–11370.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miller CT, Maves L, Kimmel CB . (2004). moz regulates Hox expression and pharyngeal segmental identity in zebrafish. Development 131: 2443–2461.

    CAS  PubMed  Google Scholar 

  • Moore SD, Herrick SR, Ince TA, Kleinman MS, Cin PD, Morton CC et al. (2004). Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Cancer Res 64: 5570–5577.

    CAS  PubMed  Google Scholar 

  • Nabirochkina E, Simonova OB, Mertsalov IB, Kulikova DA, Ladigina NG, Korochkin LI et al. (2002). Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster. Mech Dev 114: 119–123.

    CAS  PubMed  Google Scholar 

  • Nagy Z, Tora L . (2007). Distinct GCN5/PCAF-containing complexes function as coactivators and are involved in transcription factor and global histone acetylation. Oncogene 26: 5341–5357.

    CAS  PubMed  Google Scholar 

  • Nuyt AM, Szyf M . (2007). Developmental programming through epigenetic changes. Circ Res 100: 425–452.

    Google Scholar 

  • Ohta K, Ohigashi M, Naganawa A, Ikeda H, Sakai M, Nishikawa J et al. (2007). Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Biochem J 402: 559–566.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Oury F, Murakami Y, Renaud JS, Pasqualetti M, Charnay P, Ren SY et al. (2006). Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map. Science 313: 1408–1413.

    CAS  PubMed  Google Scholar 

  • Panagopoulos I, Fioretos T, Isaksson M, Samuelsson U, Billstrom R, Strombeck B et al. (2001). Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13). Hum Mol Genet 10: 395–404.

    CAS  PubMed  Google Scholar 

  • Parthun MR . (2007). Hat1: The emerging cellular roles of a type B histone acetyltransferase. Oncogene 26: 5319–5328.

    CAS  PubMed  Google Scholar 

  • Pelletier N, Champagne N, Lim H, Yang XJ . (2003). Expression, purification, and analysis of MOZ and MORF histone acetyltransferases. Methods 31: 24–32.

    CAS  PubMed  Google Scholar 

  • Pelletier N, Champagne N, Stifani S, Yang XJ . (2002). MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. Oncogene 21: 2729–2740.

    CAS  PubMed  Google Scholar 

  • Pena PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O et al. (2006). Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature 442: 100–103.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Perry J . (2006). The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins. BMC Genomics 7: 6.

    PubMed  PubMed Central  Google Scholar 

  • Rea S, Xouri G, Akhtar A . (2007). Male absent on the first (MOF): from flies to humans. Oncogene 26: 5385–5394.

    CAS  PubMed  Google Scholar 

  • Reifsnyder C, Lowell J, Clarke A, Pillus L . (1996). Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14: 42–49.

    CAS  PubMed  Google Scholar 

  • Roth SY, Denu JM, Allis CD . (2001). Histone acetyltransferases. Annu Rev Biochem 70: 81–120.

    CAS  PubMed  Google Scholar 

  • Saha V, Chaplin T, Gregorini A, Ayton P, Young BD . (1995). The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci USA 92: 9737–9741.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schroeder TM, Kahler RA, Li X, Westendorf JJ . (2004). Histone deacetylase 3 interacts with Runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem 279: 41998–42007.

    CAS  PubMed  Google Scholar 

  • Scott EK, Lee T, Luo L . (2001). Enok encodes a Drosophila putative histone acetyltransferase required for mushroom body neuroblast proliferation. Curr Biol 11: 99–104.

    CAS  PubMed  Google Scholar 

  • Seet BT, Dikic I, Zhou MM, Pawson T . (2006). Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol 7: 473–483.

    CAS  PubMed  Google Scholar 

  • Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T et al. (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442: 96–99.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Smith ER, Cayrou C, Huang R, Lane WS, Côté J, Lucchesi JC . (2005). A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol 25: 9175–9188.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Smith ER, Eisen A, Gu W, Sattah M, Pannuti A, Zhou J et al. (1998). ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci USA 95: 3561–3565.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Spencer VA, Davie JR . (1999). Role of covalent modifications of histones in regulating gene expression. Gene 240: 1–12.

    CAS  PubMed  Google Scholar 

  • Squatrito M, Gorrini C, Amati B . (2006). Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends Cell Biol 16: 433–442.

    CAS  PubMed  Google Scholar 

  • Stec I, Nagl SB, van Ommen GJ, den Dunnen JT . (2000). The PWWP domain: a potential protein–protein interaction domain in nuclear proteins influencing differentiation? FEBS Lett 473: 1–5.

    CAS  PubMed  Google Scholar 

  • Sterner DE, Berger SL . (2000). Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev 64: 435–459.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Strahl BD, Allis CD . (2000). The language of covalent histone modifications. Nature 403: 41–45.

    CAS  PubMed  Google Scholar 

  • Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P et al. (2002). Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Proc Natl Acad Sci USA 99: 11836–11841.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS et al. (2006). Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24: 841–851.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tang Y, Luo J, Zhang W, Gu W . (2006). Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 24: 827–839.

    CAS  PubMed  Google Scholar 

  • Taverna SD, Ilin S, Rogers RS, Tanny JC, Lavender H, Li H et al. (2006). Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24: 785–796.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Thomas T, Corcoran LM, Gugasyan R, Dixon MP, Brodnicki T, Nutt SL et al. (2006). Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev 20: 1175–1186.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Thomas T, Voss AK . (2007). The diverse biological roles of MYST histone acetyltransferase family proteins. Cell Cycle 6: 696–704.

    CAS  PubMed  Google Scholar 

  • Thomas T, Voss AK, Chowdhury K, Gruss P . (2000). Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development. Development 127: 2537–2548.

    CAS  PubMed  Google Scholar 

  • Thompson KA, Wang B, Argraves WS, Giancotti FG, Schranck DP, Ruoslahti E . (1994). BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID. Biochem Biophys Res Commun 198: 1143–1152.

    CAS  PubMed  Google Scholar 

  • Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E et al. (2004). Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119: 555–566.

    CAS  PubMed  Google Scholar 

  • Wade PA, Archer TK . (2006). Epigenetics: environmental instructions for the genome. Environ Health Perspect 114: A140–141.

    PubMed  PubMed Central  Google Scholar 

  • Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW et al. (2006). A protein interaction network for pluripotency of embryonic stem cells. Nature 127: 1137–1150.

    Google Scholar 

  • Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB et al. (2002). Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21CIP1/WAF1 promoter. Mol Cell Biol 22: 7982–7992.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J et al. (2006). A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 442: 86–90.

    CAS  PubMed  Google Scholar 

  • Yamamoto T, Horikoshi M . (1997). Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. J Biol Chem 272: 30595–30598.

    CAS  PubMed  Google Scholar 

  • Yang XJ . (2004). The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res 32: 959–976.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yang XJ, Grégoire S . (2007). Metabolism, cytosketon and cellular signaling in grip of protein Nɛ- and O-acetylation. EMBO Rep 8: 556–562.

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We thank Jacques Côté for sharing unpublished results about MYST protein complexes and two anonymous reviewers for constructive comments on a previous version of this paper. Related research was supported by funds from the National Cancer Institute of Canada and the Canadian Institutes for Health Research (to XJY).

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Yang, XJ., Ullah, M. MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells. Oncogene 26, 5408–5419 (2007). https://doi.org/10.1038/sj.onc.1210609

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