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Class IIa histone deacetylases: regulating the regulators

Oncogene volume 26, pages 5450–5467 (2007)Cite this article

Abstract

In the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases (HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional regulators of various developmental and differentiation processes. In the past 5 years, a tremendous effort has been dedicated to characterizing the regulation of these enzymes. In this review, we summarize the latest discoveries in the field and discuss the molecular and structural determinants of class IIa HDACs regulation. Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications.

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Acknowledgements

We apologize to those investigators whose work was not cited in this article owing to space limitations. This work was supported by the Belgian National Fund for Scientific Research (FNRS) and the Interuniversity Attraction Poles Programme, Belgian Science Policy (PAI6/28). FD is Research Associate, MM is research fellow and RK is research director of the FNRS.

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  1. Cellular and Molecular Biology Unit, FUSAGx, Gembloux, Belgium

    M Martin, R Kettmann & F Dequiedt

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Martin, M., Kettmann, R. & Dequiedt, F. Class IIa histone deacetylases: regulating the regulators. Oncogene 26, 5450–5467 (2007). https://doi.org/10.1038/sj.onc.1210613

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