Abstract
There exists considerable evidence that the growth of glial cells can be influenced by T-cell-derived lymphokines and monokines. Astrocytes proliferate in the presence of mitogen- or antigen-stimulated T-cell supernatants1–3, supernatants from human T-lymphotropic virus (HTLV)-transformed T cells3, and purified human interleukin-1 (IL-1; ref. 4). Oligodendrocytes proliferate and differentiate when incubated with supernatants from mitogen-activated or HTLV-transformed T cells3. In addition, we have recently purified a T-cell-derived lymphokine of relative molecular mass 30,000, termed glial growth promoting factor (GGPF), which specifically stimulates the proliferation of oligodendrocytes5. The traditional role of interleukins 1 and 2 is in the initiation, propagation and regulation of the immune response6. IL-1, released by a variety of cells including monocytes, stimulates T cells to produce IL-2 (ref. 7); IL-2 in turn induces the expansion of T cells that is critical for immune responsiveness. Recently, IL-2 has been shown to induce B-cell proliferation8,9 and immunoglobulin secretion10, indicating that its action is not restricted to T cells. We now report that recombinant human IL-2 influences the growth of glial cells—specifically, the proliferation and differentiation of oligodendrocytes. IL-2 may have a role in the inflammatory neural lesions of multiple sclerosis patients and in the growth of brain glia during injury or disease.
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References
Fontana, A., Otz, U., DeWeck, A. L. & Grob, P. J. J. Neuroimmun. 2, 73–81 (1982).
Fontana, A., Grieder, A., A., Arrenbrecht, S. T. & Grob, P. J. J. neural. Sci. 46, 55–62 (1980).
Merrill, J. E. et al. Science 224, 1428–1430 (1984).
Giulian, D. & Lachman, L. B. Science 228, 497–499 (1985).
Benveniste, E. N., Merrill, J. E., Kaufman, S. E., Golde, D. W. & Gasson, J. C. Proc. natn. Acad. Sci. U.S.A. 82, 3930–3934 (1985).
Gillis, S., Ferm, M. M., Ou, W. & Smith, K. A. J. Immun. 120, 2027–2032 (1978).
Larsson, E. L. & Coutinho, A. Nature 280, 239–241 (1979).
Boyd, A. W., Fischer, D. C., Fox, D. A., Schlossman, S. F. & Nadler, L. M. J. Immun. 134, 2387–2392 (1985).
Mittler, R. et al. J. Immun. 134, 2393–2399 (1985).
Kishi, H. et al. J. Immun. 134, 3104–3107 (1985).
McCarthy, K. D. & DeVellis, J. J. Cell Biol. 85, 890–902 (1980).
Suckling, A. J., Kirby, J. A. & Rumsby, M. G. Prog. Brain Res. 59, 317–322 (1983).
Raff, M. C. et al. Nature 274, 813–816 (1978).
Raff, M. C., Miller, R. H. & Noble, M. Nature 303, 390–396 (1983).
Raff, M. C., Abney, E. R., Cohen, J., Lindsay, R. & Noble, M. J. Neurosci. 3, 1289–1300 (1983).
Eisenbarth, G., Walsh, F. S. & Nirenberg, M. Proc. natn. Acad. Sci. U.S.A. 76, 4913–4917 (1979).
Bignami, A., Eng, L. F., Dahl, D. & Uyeda, C. T. Brain Res. 43, 429–435 (1972).
Mirsky, R. in Neuroimmunology (ed. Brockes, J.) 141 (Plenum, New York, 1982).
Abney, E., Williams, B. P. & Raff, M. C. Devl Biol. 100, 166–171 (1983).
Clark, S. C. et al. Proc. natn. Acad. Sci. U.S.A. 81, 2543–2547 (1984).
Sternberger, N. H., Itoyama, Y., Kies, M. W. & Webster, DeF. H. Proc. natn. Acad. Sci. U.S.A. 75, 2521–2524 (1978).
Ranscht, B., Clapshaw, P. A., Price, J., Noble, M. & Seifert, W. Proc. natn. Acad. Sci. U.S.A. 79, 2709–2713 (1982).
Roussel, G., Labourdette, G. & Nussbaum, J. L. Devl Biol. 81, 372–378 (1981).
Adams, C. W. M. Br. med. J. 33, 15–20 (1977).
Prineas, J. Hum. Path. 6, 531–554 (1974).
Raine, C. S., Scheinberg, L. & Waltz, J. M. Lab. Invest. 45, 534–536 (1981).
Traugott, U., Reinherz, E. L. & Raine, C. S. J. Neuroimmun. 4, 201–221 (1983).
Meuer, S. C. et al. J. Immun. 129, 1076–1079 (1982).
Hofman, F. et al. J. Immun. (in the press).
Fontana, A., Kristensen, F., Dubs, R., Gemsa, D. & Weber, E. J. Immun. 129, 2413–2419 (1982).
Fontana, A., Hengartner, H., de Tribolet, N. & Weber, E. J. Immun. 132, 1837–1844 (1984).
Tourtellotte, W. W. & Ma, B. I. Neurology 28, 76–83 (1978).
Kimball, E. S., Pickeral, S. F., Oppenheim, J. J. & Rossio, J. L. J. Immun. 133, 256–260 (1984).
Hendricks, S. A., Agardh, C.-D., Taylor, S. I. & Roth, J. J. Neurochem. 43, 1302–1309 (1984).
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Benveniste, E., Merrill, J. Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature 321, 610–613 (1986). https://doi.org/10.1038/321610a0
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DOI: https://doi.org/10.1038/321610a0
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