Abstract
The vertebrate hindbrain develops in a segmental pattern, with distinctive groups of neurons originating from different segments. We report here that members of the Hox-2 cluster of murine homoeobox genes are expressed in segment-specific patterns in the developing hindbrain, with successive genes having boundaries at two-segment intervals. These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues.
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Wilkinson, D., Bhatt, S., Cook, M. et al. Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature 341, 405–409 (1989). https://doi.org/10.1038/341405a0
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DOI: https://doi.org/10.1038/341405a0
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