Issue 5, 2003
From the journal:

Natural Product Reports

Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase

JoAnne Stubbe*a  and  Jiamin Tiana  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
E-mail: stubbe@mit.edu
Fax: (617) 258-7247
Tel: (617) 253-1814

Abstract

Covering: 1989 to 2003

Polyhydroxyalkanoates (PHAs) are biodegradable polymers with properties of thermoplastics. Production of these polymers in an economically competitive fashion via bioengineering requires an understanding of the biosynthetic pathway and its regulation. This review summarizes our current knowledge of the mechanism of the class I and III PHA synthases: the initiation, elongation and termination processes. It also summarizes our current understanding of the phase transition from soluble substrates (coenzyme A esters of β-hydroxyalkanoates) to insoluble granules and our understanding of the requirement for a transcription factor, phasin proteins, and depolymerases in PHA homeostasis.

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Article information

DOI
https://doi.org/10.1039/B209687K
Article type
Review Article
Submitted
16 Jul 2003
First published
14 Aug 2003

Nat. Prod. Rep., 2003,20, 445-457

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Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase

J. Stubbe and J. Tian, Nat. Prod. Rep., 2003, 20, 445 DOI: 10.1039/B209687K

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