Issue 9, 2003

Direction control in DNA binding of chiral d-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

Abstract

The DNA binding abilities of peptide nucleic acids (PNAs), both achiral and bearing three adjacent D-lysine-based monomers in the middle of the strand (“chiral box” PNA), were studied by means of electrospray mass spectrometry (ESI-MS). In contrast with achiral PNA, “Chiral box” PNA was confirmed to exert high direction control (antiparallel vs. parallel DNA target) in DNA binding.

Graphical abstract: Direction control in DNA binding of chiral d-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

Article information

Article type
Communication
Submitted
24 Dec 2002
Accepted
20 Mar 2003
First published
02 Apr 2003

Chem. Commun., 2003, 1102-1103

Direction control in DNA binding of chiral D-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry

S. Sforza, T. Tedeschi, R. Corradini, A. Dossena and R. Marchelli, Chem. Commun., 2003, 1102 DOI: 10.1039/B212718K

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