Issue 26, 2005
From the journal:

Chemical Communications

Synthesis and cellular uptake of cell delivering PNA–peptide conjugates†

Juan J. Díaz-Mochón,a   Laurent Bialy,a   Jon Watson,a   Rosario M. Sánchez-Martína  and  Mark Bradley*a  

* Corresponding authors

a School of Chemistry, Edinburgh University, Joseph Black Buildings, Edinburgh, UK
E-mail: Mark.Bradley@ed.ac.uk
Tel: 0131-6504280

Abstract

The synthesis and cellular uptake of fluorescently labelled PNA–peptide conjugates is described; Dde/Mmt protected PNA monomers, fully orthogonal to Fmoc chemistry, were used to develop a flexible strategy to give Peptide Nucleic Acids conjugated to tri- and hepta-arginine and the short basic Tat48–57 peptide as examples of cellular penetrating peptides, thereby allowing efficient cellular delivery of PNA into cells.

Graphical abstract: Synthesis and cellular uptake of cell delivering PNA–peptide conjugates

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Article information

DOI
https://doi.org/10.1039/B503777H
Article type
Communication
Submitted
15 Mar 2005
Accepted
28 Apr 2005
First published
01 Jun 2005

Chem. Commun., 2005, 3316-3318

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Synthesis and cellular uptake of cell delivering PNA–peptide conjugates

J. J. Díaz-Mochón, L. Bialy, J. Watson, R. M. Sánchez-Martín and M. Bradley, Chem. Commun., 2005, 3316 DOI: 10.1039/B503777H

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