Issue 35, 2009
From the journal:

Journal of Materials Chemistry

A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging†

Gang Huang,a   Chunfu Zhang,ab   Shunzi Li,ac   Chalermchai Khemtong,a   Su-Geun Yang,a   Ruhai Tian,a   John D. Minna,ad   Kathlynn C. Brownac  and  Jinming Gao*a  

* Corresponding authors

a Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, 5323 Harry Hines Blvd, Dallas, Texas, USA
E-mail: jinming.gao@utsouthwestern.edu
Fax: +1 214 645 6347
Tel: +1 214 645 6370

b Med-X Research Institute, Shanghai Jiaotong University, Shanghai, China

c Department of Internal Medicine, Division of Translational Research, 5323 Harry Hines Blvd, Dallas, Texas, USA
Fax: +1 214 645 6347
Tel: +1 214 645 6370

d Hamon Center for Therapeutic Oncology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas, USA
Fax: +1 214 645 6347
Tel: +1 214 645 6370

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange. The resulting SPIO particles are biocompatible and demonstrate high T2 relaxivity. The nanoprobes are specific in targeting αvβ6–expressing lung cancer cells as demonstrated by MR imaging and Prussian blue staining. This facile surface chemistry and the functional design of the proposed SPIO system may provide a powerful nanoplatform for the molecular diagnosis of lung cancer.

Graphical abstract: A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging

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Article information

DOI
https://doi.org/10.1039/B902358E
Article type
Paper
Submitted
09 Feb 2009
Accepted
24 Apr 2009
First published
29 May 2009

J. Mater. Chem., 2009,19, 6367-6372

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A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging

G. Huang, C. Zhang, S. Li, C. Khemtong, S. Yang, R. Tian, J. D. Minna, K. C. Brown and J. Gao, J. Mater. Chem., 2009, 19, 6367 DOI: 10.1039/B902358E

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