Issue 38, 2010

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

Abstract

The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.

Graphical abstract: Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2010
Accepted
05 Aug 2010
First published
25 Aug 2010

Chem. Commun., 2010,46, 7199-7201

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

R. Yang, K. K. Pasunooti, F. Li, X. Liu and C. Liu, Chem. Commun., 2010, 46, 7199 DOI: 10.1039/C0CC01382J

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