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Nanoparticles: their potential use in antibacterial photodynamic therapy

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Abstract

Photodynamic therapy (PDT) has been proposed as a new technique to inactivate microorganisms as it does not lead to the selection of mutant resistant strains; a clear benefit compared to antibiotic treatment. PDT has also attracted the interest of nanotechnology as the effectiveness of the treatment can be greatly enhanced by the use of nanoparticles. In the last decade, different approaches to the combination of nanoparticles and PDT have been investigated in relation to the antimicrobial applications of the technique. One use of the nanoparticles is to improve the delivery of photosensitiser to the bacteria; others use the nanoparticles to improve the inactivation kinetics. A different approach utilises nanoparticles as a photosensitiser. In this review these diverse types of interactions will be described.

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Authors and Affiliations

  1. Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    Stefano Perni, Jonathan Pratten & Michael Wilson

  2. Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK

    P. Prokopovich

  3. Materials Chemistry ResearchCentre, Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, UK

    Ivan P. Parkin

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  1. Stefano Perni
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Correspondence to Stefano Perni.

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This article is published as part of a themed issue on immunological aspects and drug delivery technologies in PDT.

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Perni, S., Prokopovich, P., Pratten, J. et al. Nanoparticles: their potential use in antibacterial photodynamic therapy. Photochem Photobiol Sci 10, 712–720 (2011). https://doi.org/10.1039/c0pp00360c

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