Issue 40, 2013

An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

Abstract

A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.

Graphical abstract: An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

Supplementary files

Article information

Article type
Communication
Submitted
28 Jan 2013
Accepted
28 Mar 2013
First published
28 Mar 2013

Chem. Commun., 2013,49, 4459-4461

An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

A. Fraix, N. Kandoth, I. Manet, V. Cardile, A. C. E. Graziano, R. Gref and S. Sortino, Chem. Commun., 2013, 49, 4459 DOI: 10.1039/C3CC40714D

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