REVIEWTumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells
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2022, Cancer LettersCitation Excerpt :Indeed, albeit standard therapies are based on targeting the proliferation of the rapidly growing epithelial cancer cells, stromal microenvironment plays a major role in tumor initiation and progression [42]. Tumor-stroma comprises a variety of cell types, among which the CAFs establish a cellular cross-talk with the epithelial cells in which the two cell populations mutually interplay and sustain each other contributing to tumor proliferation, invasion and metastasis [42]. Thus, in many human cancers, targeting the stromal cells has the potential to attenuate cancers progression toward invasive and metastatic fates, thereby avoiding cancer cells to evade the therapeutic effects of chemo- or radiotherapy [43].
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