Original Investigations: Pathogenesis and Treatment of Kidney Disease and HypertensionLong-term outcomes in acute renal failure patients treated with continuous renal replacement therapies☆,☆☆
Section snippets
Patients
The university hospital (Charité, Campus Mitte, Berlin, Germany) has 72 ICU beds serving general surgery, cardiac surgery, neurosurgery, orthopedics, neurology, cardiology, general internal medicine, and infectious diseases. Between January 1, 1993, and December 31, 1998, a total of 979 patients with ARF were treated with continuous renal replacement therapies in the various units. The diagnosis of ARF was based on one of the following criteria: (1) fluid overload owing to inadequate urine
Results
The in hospital mortality rate for the 979 patients with ARF was 69% (n = 678). Their clinical features are listed in Table 1.
Empty Cell Nonsurvivors Survivors P No. of patients 678 301 — Age (y) 62.2 ± 2.7 58.5 ± 13.8 NS Sex (M/F) 432/246 207/94 — APACHE II score 21.9 ± 5.1 20.5 ± 5.0 NS CRRT duration (d) 11.6 ± 13.8 17.3 ± 6.4 0.033 Etiology (%) Cardiac surgery 40* 44 — Noncardiac surgery 19* 32 — Internal
Discussion
To our knowledge, this is the first study to determine what happens to surviving patients with ARF after they leave the hospital. Although our in-hospital mortality was as dismal as that reported elsewhere, we found that subsequent survival was surprisingly good. Discharged patients had a 77% probability to survive the first 6 months. Those who made that goal had a probability of 89% to survive the following 6 months. After 5 years, the survival probability was 50%. We also observed a
References (16)
- et al.
Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: A prospective randomised trial
Lancet
(2000) - et al.
Patterns of resource consumption in medical intensive care
Chest
(1991) - et al.
ACCP/SCCM consensus conference
Chest
(1992) - et al.
The Nottingham Health Profile: Subjective health status and medical consultations
Soc Sci Med
(1981) - et al.
Prediction of requirement for, and outcome of, prolonged mechanical ventilation following cardiac surgery
Cardiovasc Surg
(1997) - et al.
Continuous venovenous high-flux dialysis in multiorgan failure: A 5-year single-center experience
Am J Kidney Dis
(1998) - et al.
Outcome prediction of acute renal failure in medical intensive care
Intensive Care Med
(1991) - et al.
Cytokine removal and cardiovascular hemodynamics in septic patients with continuous venovenous hemofiltration
Intensive Care Med
(1997)
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Address reprint requests to Stanislao Morgera, MD, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Medizinische Klinik mit Schwerpunkt Nephrologie am CCM, Schumannstr 20-21, 10098 Berlin, Germany. E-mail: [email protected]
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