Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with panic disorder
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Exposure to mass disaster and probable panic disorder among children in New York City
2021, Journal of Psychiatric ResearchTrauma-related dysfunction in the fronto-striatal reward circuit
2021, Journal of Affective DisordersCitation Excerpt :Reduced reactivity to pleasurable stimulation is a defining symptom of posttraumatic stress disorder (PTSD; American Psychological Association, 2000, 2013), suggesting reward system dysfunction. Although PTSD is the most prevalent psychopathological consequence of exposure to traumatic events (Benjet et al., 2016; Karam et al., 2014), trauma exposure also increases the severity of mental health disorders, including depression (Starr & Moulds, 2006), social anxiety (Wild et al., 2008), panic disorder (Bandelow et al., 2002), and increases suicidal behavior (Serafini et al., 2012), suggesting that reward system dysfunction might be pervasive in the internalizing disorders (Burkhouse et al., 2017; Conway et al., 2019; Lambert et al., 2018; Nusslock & Alloy, 2017; Spano et al., 2019) The fronto-striatal neural circuit – centered on the ventromedial prefrontal cortex (vmPFC) and ventral striatum - is considered a core component of the reward circuit (Berridge et al., 2009; Haber & Knutson, 2010; Kringelbach & Berridge, 2009), and is reliably engaged during affective picture perception (Sabatinelli et al., 2007; Sambuco et al., 2020; Walter et al., 2008) and in a variety of other rewarding contexts (e.g., Costa et al., 2010; Sege et al., 2017).
Greater history of traumatic event exposure and PTSD associated with comorbid body dysmorphic disorder in a large OCD cohort
2020, Psychiatry ResearchCitation Excerpt :As we noted in the introduction the cross-sectional nature of this GPCOCD study does not allow us to comment on the directionality of the onset of these comorbid conditions: OCD, BDD, MDD, and PD nor whether and which of the traumatic experiences preceded any of these disorders. However, other studies indicate that trauma might contribute to the onset of these disorders (Bandelow et al., 2002; Horesh et al., 2008; Buhlmann et al., 2012; Adams et al., 2018;; Dykshoorn, 2014). More specifically in BDD, stressful life events have included high rates of perceived childhood abuse and neglect (Didie et al., 2006) and reported instances of teasing and bullying in adolescence, have triggered the onset of BDD symptoms (Weingarden et al. (2017);Buhlmann et al., 2012).
Developmental risk factors in generalized anxiety disorder and panic disorder
2016, Journal of Affective DisordersAre there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis
2015, European PsychiatryCitation Excerpt :The prevalence of sexual abuse ranged from 9.0% to 35.0% for those with PD and 10.0% to 23.8% for those with SAD, and it was 25.0% for those with GAD. With respect to the association between EET and PD, all studies that used healthy subjects as the control group (n = 6 [7,9,23,33,44,67]) reported higher prevalence rates of physical, emotional, and sexual trauma among individuals with PD. Only one study [44] reported no differences in the rate of sexual trauma between these groups.