Basic–Alimentary TractFull-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome☆,☆☆
Section snippets
Patient selection
Consecutive patients who met the inclusion criteria and agreed to participate were included in the study between 1998 and 1999. All patients were seen at the Department of Gastroenterology and Hepatology, Huddinge University Hospital, Stockholm, Sweden. The inclusion criteria were the following: (1) fulfillment of the Rome-I Criteria for the Diagnosis of IBS, (2) need for referral to a specialist in gastroenterology, (3) sick listing from work because of IBS symptoms for more than 1 month
Results
Eight women and 2 men with severe IBS were studied. The average age was 40 years (range, 23–57 years). All patients underwent laparoscopy-assisted full-thickness biopsy of the jejunum from which the patient-related results below were obtained. The postoperative period was uneventful, and all patients were discharged on the first postoperative day. Brief patient characteristics were as follows:
Female 45 years of age, constipation-predominant IBS. Dyspeptic symptoms during many years. Developed
Discussion
The results of our study must be interpreted with caution. We found histopathologic abnormalities of the proximal jejunum in patients whose diagnosis was based on the absence of structural lesions and fulfilling the Rome I criteria for IBS. The patients were from different age groups and could be divided into all categories of IBS. There were coexisting diseases in the group but nothing that interferes with the IBS diagnosis and, most importantly, that can explain our findings. We observed 5
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Cited by (0)
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Address requests for reprints to: Hans Törnblom, M.D., Karolinska Institutet Department of Medicine at Huddinge University Hospital, Division of Gastroenterology and Hepatology, K63 SE-141 86 Huddinge, Sweden. e-mail: [email protected]; fax: (46) 8 585 823 35.
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Supported by a research grant from the Swedish Society of Medicine (Bengt Ihres fond).