Original ContributionsMorphologic typing of papillary renal cell carcinoma: Comparison of growth kinetics and patient survival in 66 cases*
Section snippets
Materials and methods
Sixty-eight cases of papillary renal cell carcinoma were identified from a population-based case-control study of renal cell carcinoma in New South Wales13 and from the files of Wellington Hospital. The blocks were reviewed, sections were cut from the blocks, and the histology was reviewed independently by 2 pathologists (B.D. and J.N.E.). The tumors were classified as type 1 papillary renal cell carcinoma and type 2 papillary renal cell carcinoma according to previously reported criteria.11
Results
There were 54 men and 14 women in the series with age at presentation ranging from 26 to 86 (mean, 63.0) years. The review of tumor histology showed 52 cases to be type 1 and 16 to be type 2. There were 43 men and 9 women with type 1 tumors and 11 men and 5 women with type 2 tumors. Patient age at presentation ranged from 26 to 86 (mean, 62.3) years for type 1 tumors and 34 to 83 (mean, 65.3) years for type 2 tumors. There was no significant difference in sex distribution (Fisher exact P =.29)
Discussion
Early series that compared the histopathology and clinical features of papillary renal cell carcinoma and other types of renal cell carcinoma (predominantly clear cell renal cell carcinoma) showed that papillary renal cell carcinoma was associated with a more favorable prognosis.2 It was subsequently noted that a higher proportion of papillary renal cell carcinomas were organ-localized at the time of diagnosis and that low-stage tumors had a higher 5-year survival rate than clear cell renal
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Address correspondence and reprint requests to Brett Delahunt, MD, FRCPA, Department of Pathology and Molecular Medicine, Wellington School of Medicine, PO Box 7343, Wellington South, New Zealand.