Original ContributionsGenetic alterations in epithelial ovarian tumors analyzed by comparative genomic hybridization*
Section snippets
Patient characteristics
The study group comprised 45 patients presenting with benign or malignant tumors of the ovary (Table 1).We studied 9 patients with benign lesions; 5 patients had serous cystadenomas (mean age, 60 years; mean size, 52 mm; 3 left, 2 right), 1 28-year-old patient had an endometriotic cyst, and 3 patients had benign Brenner tumors (mean age, 43 years; mean size, 35 mm; 2 right, 1 left).
Eleven LMP tumors from 10 patients of mean age 51 years were investigated: 5 of these tumors were serous, 3 were
Results
Chromosomal imbalances were found in only 1 serous adenoma, which had losses on 1p36, 19, and 22 (Table 2).Aberrations were found in 7 of 11 LMP tumors (5 serous, 1 mucinous, and 1 endometrioid). On average, there were 4.0 gains and 3.8 losses. The losses were found most consistently on 1p36, 16p, 19, and 22, the former on 3p26 (Table 2). In the group of serous LMP tumors, we found 3.6 gains and 4.7 losses. The bilateral LMP tumor studied had very similar chromosomal imbalances on both sites
Discussion
Although various genetic studies on ovarian cancer have been performed, no consistent pattern of genetic alterations has been defined until now. The reason for this lack of consistency is that most of these studies use heterogeneous tumor material, mixing not only the various histologic types of ovarian cancer, but also germ cell tumors and epithelial tumors.9, 10, 11, 12 Moreover, the different methods used to analyze genetic alterations reduce the comparability of the studies. This has been
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Address correspondence and reprint requests to Steffen Hauptmann, MD, Institute of Pathology, Charité Hospital Berlin, Schumannstr. 20/21, D-10117 Berlin, Germany.