Original Investigation: Pathogenesis and Treatment of Kidney Disease and HypertensionThe relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
Section snippets
Methods
Recruitment methods for the CHS have been published.19 In brief, a random sample of individuals aged 65 years or older derived from Medicare eligibility lists and their spouses were invited to participate at 4 field centers. Potential participants were excluded if they had cancer under active treatment or would not have been able to attend a field center for examination. A total of 5,201 participants were recruited in 1989 to 1990 (called the original cohort), and 687 participants in 1992 to
Results
Albuminuria status, categorized by the presence or absence of diabetes and/or hypertension, is listed in Table 1. Microalbuminuria was present in 15.9% of the cohort; 7.7% of those with neither hypertension nor diabetes, 16.7% of those with hypertension only, and 31.2% of those with diabetes with or without hypertension. Subjects with macroalbuminuria were excluded from additional analyses.
Discussion
In this study, microalbuminuria was associated with elevated levels of several inflammatory factors in the presence or absence of hypertension or diabetes. The association of inflammatory factors with microalbuminuria also was present regardless of whether CVD, which may increase levels of inflammatory factors, was present. Many of the same inflammatory factors associated with microalbuminuria also were associated with CHD. Together, these results suggest an association between
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