Original InvestigationPathogenesis and Treatment of Kidney DiseaseHepatitis C Seropositivity and Kidney Function Decline Among Women With HIV: Data From the Women's Interagency HIV Study
Section snippets
Study Participants
Women in this study were participants in the Women's Interagency HIV Study (WIHS), a multicenter prospective cohort study of the natural history, including treatment, of HIV infection. Full details of recruitment and baseline cohort characteristics have been described previously.9, 10 The WIHS enrolled women who were either infected with HIV (Western blot confirmed) or at risk of HIV infection between October 1994 and November 1995 and again between October 2001 and September 2002 from 6
Results
Of 2,791 HIV-positive women in WIHS, 2,702 (97%) had HCV serological results (Fig 1). Of those 2,702 women, 18 (0.7%) were missing baseline serum creatinine measurement and were excluded from the analysis, leaving a final study population of 2,684 women. Women who were missing HCV serological or baseline serum creatinine results (n = 107; 3.8% of the original 2,791) were slightly older (mean age, 37 ± 8 [SD] versus 35 ± 8 years; P = 0.008) and more likely to use injection drugs (47% versus 33%;
Discussion
In this study of HIV-infected women, HCV seropositivity was associated with a slightly lower eGFR over time in women who had eGFR less than 60 mL/min/1.73 m2 at baseline. In contrast, it did not appear to be associated with a lower eGFR over time in women with baseline eGFR of 60 mL/min/1.73 m2 or greater. The association between HCV seropositivity and decrease in renal function was statistically significant even after adjusting for demographic factors, illicit drug use, diabetes, hypertension,
Acknowledgements
The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Support: WIHS is funded by the National Institute of Allergy and Infectious Diseases (UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-A1-34989, UO1-AI-34993, and UO1-AI-42590) and the National Institute of Child Health and Human Development (UO1-HD-32632). The study is cofunded by the National Cancer Institute, National Institute on
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Cited by (34)
KDIGO 2022 Clinical Practice Guideline FOR the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease
2022, Kidney InternationalCitation Excerpt :Although studies are heterogeneous and some controversy persists,65 overall, HCV-infected patients appear to be at greater risk for incidence and progression of kidney disease and require monitoring as outlined in the KDIGO CKD guideline.53 In the Women’s Interagency HIV study, anti-HCV–positive serologic status was independently associated with a net decrease in eGFR of approximately 5% per year (95% CI: 3.2–7.2) compared with women who were seronegative.66 Of note, antiviral therapy for HCV significantly improves hepatic and extrahepatic outcomes in the general population67,68 and among patients co-infected with HIV and HCV.69
Liver Disease and Chronic Kidney Disease
2019, Chronic Renal DiseaseKDIGO 2018 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease
2018, Kidney International SupplementsCitation Excerpt :Although studies are heterogeneous and some controversy persists,68 overall, HCV-infected patients appear to be at greater risk for incidence and progression of kidney disease and require monitoring as outlined in the KDIGO CKD guideline.56 In the Women’s Interagency HIV study, anti-HCV–positive serologic status was independently associated with a net decrease in eGFR of approximately 5% per year (95% CI: 3.2–7.2) compared with women who were seronegative.69 Of note, antiviral therapy for HCV significantly improves hepatic and extrahepatic outcomes in the general population70,71 and among patients co-infected with HIV and HCV.72
Hepatitis C and its metabolic complications in kidney disease
2017, Annals of HepatologyCitation Excerpt :The relationship between anti-HCV antibody positive status and chronic kidney disease has been also addressed among HIV infected populations. In the Women's Intera-gency HIV study, anti-HCV positive serologic status was independently associated with a fully adjusted net decrease in eGFR of approximately 5% per year (95% confidence interval, 3.2 to 7.2) relative to women who were seronega-tive.53 One systematic review had been already published on the impact of HIV/HCV co-infection on the incidence of CKD;54 we performed a meta-analysis and retrieved 19 studies (n = 146,1151 unique patients with HIV infec-tion).55
Aging with HIV in the ART era
2017, Seminars in Diagnostic PathologyNovel evidence on hepatitis C virus-associated glomerular disease
2014, Kidney International
Originally published online as doi: 10.1053/j.ajkd.2009.02.009 on April 27, 2009.