Clinical-alimentary tractFertility and pregnancy-related events in women with celiac disease: A population-based cohort study
Section snippets
Materials and methods
We obtained data from the General Practice Research Database (GPRD), a source of longitudinal records of routine primary care visits for more than 8 million people registered at general practices across the United Kingdom.21, 22 Participating practices must record all major diagnoses, medical events, and prescriptions, and audits are performed regularly to ensure that practice data are kept up to standard by including at least 95% of this information. Aggregated data are anonymized for research
Study population
From our initial cohort of 4732 people with celiac disease and 23,620 comparison subjects,28 we identified 1521 and 7732 potentially fertile women, respectively, who were included in our study. There were no differences in the age at first birth (χ2 test for trend; P = .76) or in the total number of births between the 2 cohorts (χ2 test for trend; P = .87) (Table 1). Women with celiac disease were more likely to have never smoked (χ2; P < .01) and to have a lower body mass index (χ2 test for
Discussion
In this large general population–based cohort study, we found that overall fertility rates are the same in women with diagnosed celiac disease compared with women in the general population. However, women with celiac disease tend to have their babies at an older age. The pattern of relative fertility increasing with age was similar in women with prevalent or incident celiac disease in our study. Within the incident group, we were additionally able to investigate whether their fertility changed
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Automated interpretation of biopsy images for the detection of celiac disease using a machine learning approach
2021, Computer Methods and Programs in BiomedicineCitation Excerpt :Celiac disease can affect individuals of any age; with peaks observed during childhood (< 6 years old) and 40–50 years of age [5,6]. Patients can experience multiple complications such as osteoporosis [7], decreased fertility in women [8], gastrointestinal malignancies [9], intestinal B- and T- cell lymphomas [10,11] and cardiac maladies [12] if celiac disease is not diagnosed early after its development. Thus, it is crucial to diagnose celiac disease early for efficacious treatment.
No Increased Risk of Cardiac Birth Defects in Infants of Mothers with Celiac Disease: A Population and Sibling Comparison
2023, American Journal of GastroenterologyDevelopment of a nutrition screening tool to identify need for dietetic intervention in female infertility
2023, Journal of Human Nutrition and DieteticsAdverse pregnancy outcomes in women with celiac disease: a systematic review and meta-analysis
2023, Annals of Gastroenterology
Supported by The Wellcome Trust (grant 063800).