Clinical–alimentary tractRisk of Intestinal Cancer in Inflammatory Bowel Disease: A Population-Based Study From Olmsted County, Minnesota
Section snippets
Patient Population
A total of 692 Olmsted County, Minnesota, residents (378 UC, 314 CD) first were diagnosed with IBD in Olmsted County, Minnesota, during the period from 1940 to 2001, according to previously established well-defined criteria.22, 23, 24 Olmsted County, situated in southeastern Minnesota, had a population of 124,277 inhabitants in the 2000 US census. The majority of people reside in Rochester, which is the urban center of an otherwise rural county. Eighty-nine percent are non-Hispanic white and a
Results
The 692 IBD patients were followed up for a total of 10,470 person-years (median follow-up period, 14 years; range, 0–58 years). However, only 10,019 person-years occurred before total proctocolectomy and were available for analysis of CRC risk. A total of 118 patients (17%) died within the study period.
A total of 378 patients (44% women) with UC were followed up for a total of 5567 person-years (median follow-up period, 12.6 years; range, 0.0–57.6 years) before proctocolectomy. The median age
Discussion
In this population-based study from North America, the CRC risk among UC patients overall was similar to that expected in the general population. Among patients with extensive colitis, the CRC risk was increased 2-fold, although this did not meet statistical significance. In CD, the risk for CRC was somewhat increased overall, but was not statistically significant. In a subset of male CD patients with young age at diagnosis, the CRC risk was increased. The risk for small-bowel cancer in the CD
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Cited by (0)
Supported by the Mayo Foundation for Medical Education and Research, AR30582 from the National Institutes of Health, the Astra Zeneca Travel Foundation (visit to Mayo Clinic by T.J.), Augustinus Foundation, Beckett Foundation, Danish Crohn Colitis Foundation, Jacob Madsen and Olga Madsen Foundation, and Sigrid R. Moran Foundation.