Original ResearchClinical—Alimentary TractPediatric Patients With Dyspepsia Have Chronic Symptoms, Anxiety, and Lower Quality of Life as Adolescents and Adults
Section snippets
Sample
The study entailed a secondary analysis of an existing database of pediatric patients and community controls. The patient sample was drawn from several studies conducted by Walker et al32, 33, 34 between 1993 and 2004. Consecutive new patients referred to Vanderbilt Pediatric Gastroenterology Clinic for evaluation of abdominal pain were eligible for those studies if they were between the ages of 8 and 16 years, had abdominal pain of at least 3 months' duration, no chronic illness or disability,
Results
Figure 1 describes patient recruitment and the study timeline. Seven patients who underwent upper endoscopy but experienced fewer than 2 dyspeptic symptoms were excluded. Based on a review of medical records, 4 patients with Crohn's disease and 1 patient with cholelithiasis also were excluded. Thus, the final sample consisted of 183 pediatric patients with 2 or more dyspeptic symptoms who underwent endoscopy with biopsies. Of those whose upper endoscopy showed histologic reflux esophagitis, 50
Conclusions
This prospective cohort study of pediatric patients evaluated with upper endoscopy makes two important contributions to the literature. First, we found that these pediatric patients with dyspeptic symptoms, both with and without abnormal esophageal histology, had more dyspeptic symptoms, greater functional disability, and poorer health-related quality of life compared with controls in adolescence and young adulthood. Related studies have reported poorer health-related quality of life in
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Conflicts of interest The authors disclose no conflicts.
Funding Supported by grants R01 HD23264 (Walker), T32DK007673 (Rippel), DK058404 (Vanderbilt Digestive Disease Research Center), UL1 RR024975 (Vanderbilt CTSA, National Center for Research Resources), P30 HD15052 (Vanderbilt Kennedy Center).