Regular ArticlesAntisense oligonucleotides to the integrin receptor subunit alpha5 decrease fibronectin fragment mediated cartilage chondrolysis
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Keywords
Integrin, Fibronectin fragments, Antisense, Cartilage
Abbreviations
Fn-fs, fibronectin fragments
MMP, matrix metalloproteinase
Fn, fibronectin
PG, proteoglycan
MMP-3, stromelysin-1
DMEM, Dulbecco's modified Eagle's medium
DMB, dimethylmethylene blue
oligos, oligonucleotides
ASO, anti-sense oligos
SO, sense oligos
SCO, scrambled oligos
LPS, lipopolysaccharide.
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Address correspondence to: Gene A. Homandberg, Ph.D., Department of Biochemistry, Rush-Presbyterian-St Luke's Medical Center, 1653 West Congress Parkway, Chicago, IL 60612-3864, U.S.A. Tel: (312) 942-5468; Fax: (312) 942-3053; E-mail:[email protected]
Copyright © 2002 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.