Leukocyte adhesion and hepatic microvascular responses to intestinal ischemia/reperfusion in rats
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Hepatic Ischemia/Reperfusion Injury involves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population
2021, International ImmunopharmacologyCitation Excerpt :Taken together, we suggest that tryptase may be derived from the gastrointestinal and/or other organs MCs during liver IR. Previous studies showed that neutrophil accumulation also appeared in the liver after intestinal IR [50]. This agreed with our view.
Reperfusion therapy—What's with the obstructed, leaky and broken capillaries?
2017, PathophysiologyValue of the portal venous phase in evaluation of treated hepatocellular carcinoma following transcatheter arterial chemoembolisation
2017, Clinical RadiologyCitation Excerpt :Following embolisation and subsequent collateral formation, ischaemia–reperfusion injury to liver tissue has been known to incite an inflammatory response via mediators, such as tumour necrosis factor-alpha and reactive oxygen species, leading to recruitment of circulating leukocytes to the sinusoids.33,34 In animal models, the leukocytes accumulate and adhere within the microvasculature and establish sinusoidal plugging and stagnation of flow without complete cessation in the sinusoids.12,35–38 The reduction in inflow has been theorised to result in diminished outflow of blood and blood products.13,39
The periosteal microcirculation in health and disease: An update on clinical significance
2017, Microvascular ResearchCitation Excerpt :If more accurate detection or improved spatial resolution of the microcirculation is needed, traditional fluorescence IVM can provide an opportunity for real-time examination of the microcirculation of superficial layers. Conventional fluorescence IVM visualizes not only changes in the efficacy of microvascular perfusion, but also cell-cell (e.g. polymorphonuclear leukocyte (PMN)–endothelial cell) interactions, such as rolling and adhesion, vascular diameter changes or signs of apoptosis (Abshagen et al., 2006; Horie et al., 1996) (see Fig. 1 A–D). Non-fluorescence techniques, including orthogonal polarization spectral imaging (OPS) (Groner et al., 1999) (Fig. 1 E–F) and sidestream dark-field imaging, have also been developed for the imaging of individual vessels and cells (Milstein et al., 2010).
Methylene blue protects liver oxidative capacity after gut ischaemia-reperfusion in the rat
2013, European Journal of Vascular and Endovascular Surgery