Alimentary TractA new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development☆
Section snippets
Animals
Experiments were performed using male Sprague–Dawley rats obtained as preweanling neonates (younger than 8 days) from Harlan Sprague–Dawley Inc. (Indianapolis, IN). Rats were housed in plastic cages containing corn chip bedding (Sani-Chips; PJ Murphy Forest Products, Montville, NJ) and maintained on a 12:12-hour light-dark cycle (lights on at 7 AM). The irritation procedure and the experimental testing were conducted during the light component of the cycle. The neonates were housed 12 in a cage
Results
CI in neonatal rats leads to a state of chronic visceral hypersensitivity in adults manifested by increased contractility of abdominal muscles and hyperexcitability of viscerosensitive neurons in the lumbosacral cord. This hypersensitivity occurs in the absence of identifiable histopathology in the adult colon and does not alter the growth rate of the rats with CI. In fact, sections from the colons of 12 rats (4 with neonatal CRD, 4 with neonatal mustard oil treatment, and 4 controls) were
Discussion
Pain is a central feature in the lives of patients with IBS; in the more severe cases, it can be prominent enough to give rise to the term “pain career.”10 The lack of overt visceral pathology, along with reported associations with childhood sexual, physical, and verbal abuse, has resulted in several psychologic hypotheses to explain this so-called functional abdominal pain.6 Alternatively, such pain may be the result of sensitization of the nervous system at a vulnerable state in its
Acknowledgements
The authors thank Dr. Shu-Yuan Xiao, Department of Pathology, University of Texas Medical Branch, for his expert evaluation of the colonic tissues.
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Address requests for reprints to: Elie D. Al-Chaer, Ph.D., Departments of Internal Medicine and Anatomy and Neurosciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0632. e-mail: [email protected]; fax: (409) 747-3084.