Clinical ResearchRectal distention testing in patients with irritable bowel syndrome: Sensitivity, specificity, and predictive values of pain sensory thresholds☆,☆☆
Section snippets
Materials and methods
This study is a retrospective analysis of the activity in our laboratory between 1997 and 2000.
Characteristics of patients
Characteristics of the study groups are given in Table 1.Empty Cell Controls IBS Functional constipation Functional dyspepsia Miscellaneous Empty Cell Number 25 86 26 21 31 — Age (yr)a 39 ± 8.1 44.9 ± 6.6 45.6 ± 15.2 44.4 ± 7.8 43.1 ± 5.5 NS Female/male 17/8 60/26 20/6 17/4 24/7 NS aMean ± SD.
Discussion
The aim of this study was to determine the sensitivity, specificity, and the predictive value of pain thresholds to rectal distention evaluated by electronic barostat in 25 normal controls and in 164 patients with different FBDs. Our study showed that: (1) IBS patients displayed lowered pain thresholds in response to rectal distention when compared with normal controls. (2) Rectal pain threshold in IBS patients was significantly lower than in other patients with abdominal pain from various
Acknowledgements
The authors thank Mr. Ovide D'asilva for his assistance in English edition.
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Address requests for reprints to: Pierre Poitras, M.D., Hôpital Saint-Luc DU chum, 1058, St-Denis Street, Montreal, (QC) - H2X 3J4 Canada. e-mail: [email protected]; fax: (514) 412-7314.
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Supported by an operating grant from the Medical Research Council of Canada (to P.P.) and by a Research Fellowship (to Mickael Bouin) from the Canadian Association of Gastroenterology, Canadian Institutes of Health Research, and Astra Zeneca Canada Inc.