State of the artThe Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy
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2021, Ecotoxicology and Environmental SafetyCitation Excerpt :High levels of IL-10 in patients with acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin’s lymphomas have been associated with poor response to treatment (de Totero et al., 1999; Lappin and Campbell, 2000). This could be because as a negative regulator mainly secreted by Th2 cells, IL-10 mediates the switch to an ineffective type-2 immune response, which provides an immune escape mechanism for malignant tumors (Lappin and Campbell, 2000). Aplastic anemia involves Th1 cell hyperfunction, which is negatively correlated with hematopoietic function: significant increase in the number of Th1 cells and CD3+ CD8+ Th1 type effector cells as well as Th1 type cytokine (TNF-α) levels have been found in patients with aplastic anemia (Solomou et al., 2006).
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences
2018, Journal of Controlled ReleaseCitation Excerpt :These danger signals stimulate DCs to upregulate the expression of co-stimulatory molecules including CD40, CD80 (B7.1), CD86 (B7.2) and MHC-I/II molecules and to produce TH1 cytokines, such as interleukine-12 (IL-12) and interferon gamma (IFN-γ). These TH1 polarizing signals are necessary to effectively prime naïve CD4 T cells into TH1 cells [17,18]. TH1 cells and DCs form subsequent cognate pairs with naïve CD8 T cells to develop them into CTLs, which then enter the blood to seek and destroy cancer cells.
Glucocorticoids and immunity
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