Original ArticleCo-expression of GH and GHR isoforms in prostate cancer cell lines
References (58)
- et al.
Proliferative disorders of the aging human prostate: involvement of protein hormones and their receptors
Exp Gerontol
(1999) - et al.
Antagonistic analogs of growth hormone releasing hormone: new potential antitumour agents
Trends Endocrinol Metab
(1999) - et al.
Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats
Mol Cell Endocrinol
(1992) - et al.
Developmental expression of the growth hormone receptor gene in rabbit tissues
Mol Cell Endocrinol
(1992) - et al.
Expression and binding properties of two isoforms of the human growth hormone receptor
FEBS Lett
(1993) - et al.
Splicing variants of human growth hormone mRNA: detection in pituitary, mononuclear cells and dermal fibroblasts
Mol Cell Endocrinol
(1995) - et al.
Mode of autocrine/paracrine mechanism of growth hormone action
Exp Cell Res
(1997) - et al.
Characterisation of ALVA-41 cells, a human prostatic cancer cell line
Steroids
(1994) - et al.
Monkey growth hormone (GH) receptor gene expression
J Biol Chem
(1997) - et al.
Evolutionary divergence of the truncated growth hormone receptor isoform in its ability to generate a soluble growth hormone binding protein
Mol Cell Endocrinol
(1998)
Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture
Cancer Res
Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
Science
Hormonal predictors of prostate cancer: a meta-analysis
J Clin Oncol
Serum insulin-like growth factor 1 is not a useful marker of prostate cancer
Br J Urol Int
Growth hormone directly affects the function of the different lobes of the rat prostate
Endocrinology
Growth hormone receptor expression in the Dunning R 3327 prostatic carcinoma of the rat
Prostate
Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development
Endocrinology
Growth hormone binding and stimulation of amino acid uptake in epithelial cells of rat ventral prostate
Cell Biochem Funct
Cellular localization of the growth hormone receptor/binding protein in the male and female reproductive systems
Endocrinology
Expression of growth hormone receptor in human prostatic carcinoma and hyperplasia
Int J Oncol
Growth hormone binding proteins
Antitumorigenic actions of growth hormone releasing hormone antagonists
Proc Natl Acad Sci USA
GHRH. A potential autocrine pathway for growth hormone releasing hormone (GHRH) and its receptor in human prostate cancer cell lines
Prostate
Cloning of two novel growth hormone transcripts expressed in human placenta
J Clin Endocrinol Metab
Human growth hormone gene expression in pituitary and placenta
Human Growth Hormone Pharmacology: Basic and Clinical Aspects
Distribution and abundance of messenger ribonucleic acid for growth hormone receptor isoforms in human tissues
J Clin Endocrinol Metab
Nucleotide sequence of a full-length cDNA for mouse cytoskeletal beta-actin mRNA
Nucl Acids Res
Characterization of the growth hormone-binding protein of human serum using a panel of monoclonal antibodies
J Endocrinol
Cited by (37)
Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor
2018, European Journal of Medicinal ChemistryCitation Excerpt :The endogenous ligand for GHS-R1a is ghrelin, a 28-mer peptide with an n-octanoyl group on the Ser3 side-chain, which was discovered in 1999 [15] and exhibits a multitude of biological activities, such as the regulation of food intake and glucose metabolism [16,17]. The ghrelin receptor is expressed in a number of human malignancies including prostatic carcinoma cell lines [18,19] and tissues [20], breast carcinoma tumours and cell lines [21], testicular tumours [22], and malignant ovarian cysts and tumours [23]. In addition, it has an elevated level of expression in tissues from patients with atherosclerosis [24] and in biopsies from those with chronic heart failure [25].
Extrapituitary growth hormone in the chicken reproductive system
2014, General and Comparative EndocrinologyCitation Excerpt :The expression of the GH gene has also been demonstrated in normal prostate biopsies (Slater and Murphy, 2006), suggesting GH involvement in prostate function. Indeed GH is thought to be involved in prostate development (Reiter et al., 1995; Ruan et al., 1999) and in cell proliferation and survival in prostate cancer cell lines (Untergasser et al., 1999; Nakonechnaya et al., 2013), in which the GH gene is expressed (Chopin et al., 2002; Nakonechnaya et al., 2013). GH is thought to contribute to prostate cancer, since it increases androgen receptor abundance (Reiter et al., 1999) and prostate cancer is abrogated in genetic rodents with GHR deficiency (Wang et al., 2005, 2008).
Evolutionary origin and divergence of the growth hormone receptor family: Insight from studies on sea lamprey
2013, General and Comparative EndocrinologyCitation Excerpt :Besides the soluble GHBPs produced by alternative splicing, it appears that most of the truncated receptors that have been characterized result in a receptor with an altered intracellular domain. However, in several human prostate cancer cell lines, an expressed truncated receptor was found to be missing exon 3, which encodes the N-terminal portion of the extracellular domain to result in a receptor that is 22 amino acids shorter in length and that has an unknown physiological relevance (Chopin et al., 2002). Alternative splicing has also been found to be responsible for a long form of GHR in black sea bream, which includes an additional alternative splice site not characterized in any other organism (Tse et al., 2003).
The role of Stat5 transcription factors as tumor suppressors or oncogenes
2011, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Interestingly, a recent study with breast epithelial cells links Stat5 activation with increased cell survival upon Prl action through direct transcriptional activation of the Akt1 kinase [71]. A large fraction (~ 95%) of hormone refractory prostate cancer displays persistent Stat5 activity [72], often in association with GH and Prl expression [73,74]. A mouse model of Stat5 activation by Prl recapitulates prostate tumorigenesis from precancerous lesions to invasive carcinoma [75].
Unexploited therapies in breast and prostate cancer: Blockade of the prolactin receptor
2010, Trends in Endocrinology and MetabolismCitation Excerpt :Although most attention has focused on the GH-IGF-1 axis, a direct role for GH has also been demonstrated. As depicted in Tables 1 and 2, both hGH and the GHR are expressed in breast and prostate tissues and in some cell lines [37ā39]. The involvement of local hGH in breast cancer has been extensively studied by Lobie et al., who used MCF-7 cells stably transfected with intact or mutated hGH genes (reviewed in [35]).
Regulation of growth hormone receptors in human prostate cancer cell lines
2009, Molecular and Cellular Endocrinology
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L.K. Chopin, Centre for Molecular Biotechnology, Queensland University of Technology, GPO Box 2434, Brisbane, Q 4001, Australia. Tel: +61 7 38642667; Fax: +61 7 3864 1534; E-mail: [email protected]