Regular ArticleElevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome
References (126)
- et al.
Immunologically mediated fatigue: a murine model
Clin Immunol Immunopathol
(1992) - et al.
Susceptibility to immunologically mediated fatigue in C57BL/6 versus Balb/c mice
Clin Immunol Immunopathol
(1996) - et al.
Nitric oxide and inflammatory athritides
Life Sci
(1997) - et al.
N-acetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes
Free Radic Biol Med
(1998) - et al.
Inhibition of mitochondrial electron transport by peroxynitrite
Arch Biochem Biophys
(1994) - et al.
Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide
J Biol Chem
(1994) - et al.
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles
Arch Biochem Biophys
(1996) - et al.
NF-IL6 and NF-κB in cytokine gene regulation
Adv Immunol
(1997) - et al.
NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
Adv Immunol
(1997) Modification of inflammatory aspects of immune function by nutrients
Nutr Res
(1998)
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells
Gastroenterology
A peroxidative model of human erythrocyte intracellular Ca2+changes with in vivo cell aging: measurement of 19F-NMR spectroscopy
Biochim Biophys Acta
Modification of inflammatory aspects of immune function by nutrients
Nutr Res
Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells
Free Rad Biol Med
Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers
J Affect Disord
Neuroendocrine correlates of chronic fatigue syndrome: a brief review
J Psychiatr Res
Induction of nitric oxide synthase and interleukin-1β, but not heme oxygenase, messenger RNA in rat brain following peripheral administration of endotoxin
Mol Brain Res
Evidence for a role of nitric oxide in the corticotropin-releasing factor release induced by interleukin-1β
Eur J Pharmacol
Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus
Brain Res
Altered cytokine release in peripheral blood mononuclear cell cultures from patients with chronic fatigue syndrome
Cytokine
Cytokine production by adherent and non-adherent mononuclear cells in chronic fatigue syndrome
J Psychiatr Res
A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia
Blood
Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome
Neurosci Lett
Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy
Chest
Preliminary determination of a molecular basis to chronic fatigue syndrome
Biochem Mol Med
Preliminary determination of the association between symptom expression with urinary metabolites in subjects with chronic fatigue syndrome
Biochem Mol Med
Post-viral fatigue syndrome, viral infections in atopic eczema, and essential fatty acids
Med Hypotheses
Low NK syndrome and its relationship to chronic fatigue syndrome
Clin Immunol Immunopathol
Gender differences in host defense mechanisms
J Psychiatr Res
Ibuprofen: effect on inducible nitric oxide synthase
Brain Res Mol Brain Res
1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system
Brain Res Mol Brain Res
Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells
FEBS Lett
Inhibition of inducible nitric oxide synthase gene expression and enzyme activity be epigallocatechin gallate, a natural product from green tea
Biochem Pharmacol
Chronic fatigue syndrome: an update
Ann Rev Med
Postviral Fatigue Syndrome, Br Med Bull, vol 47
The Doctor's Guide to Chronic Fatigue Syndrome
Immunology of postviral fatigue syndrome
Br Med Bull
Clinical spectrum of postviral fatigue syndrome
Br Med Bull
Studies of enterovirus in patients with chronic fatigue syndrome
Clin Infect Dis
Clinical presentation of chronic fatigue syndrome
Ciba Foundation Symp
Pathological implications of nitric oxide, superoxide and peroxynitrite formation
Biochem Soc Trans
Nitric oxide, superoxide and peroxynitrite: the good, the bad and the ugly
Am J Physiol
The chemistry of peroxynitrite: a product from the reaction of nitric oxide and superoxide
Am J Physiol
IL-6 induction of protein–DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter: role of octamer binding proteins
J Immunol
Inhibition of nuclear factor κ B attenuates proinflammatory cytokine and inducibe nitric-oxide synthase expression in postischemic myocardium
Biochim Biophys Acta
IL-1-induced iNOS expression in human astrocytes via NF-κB
Neuroreport
Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma
Hepatology
Nitric oxide in sepsis-syndrome: potential treatment of septic shock by nitric oxide synthase antagonists
Kidney Int
Nitric oxide and sepsis
Respir Care Clin N Am
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation and mitochondrial dysfunction
J Neurosci
Cited by (95)
How chronic administration of benzodiazepines leads to unexplained chronic illnesses: A hypothesis
2018, Medical HypothesesCitation Excerpt :Increasing any of the cycle elements illustrated above, i.e. a short-term stressor, can initiate the NO/ONOO(−) self-perpetuating cycle, and the multiple interacting vicious cycles therein explain the chronic nature of NO/ONOO(−) cycle diseases [49]. As depicted in the illustration, nitric oxide and superoxide react in a very rapid, diffusion limited reaction to form peroxynitrite (OONO−) [47]. Again, nitric oxide is synthesized by three different isozymes of nitric oxide synthase, two of which are constitutive, eNOS and nNOS and one of which is highly inducible, iNOS [47].
Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery
2017, Journal of Pain and Symptom ManagementCitation Excerpt :NOS1 is part of a group of NOS responsible for the synthesis of NO. NO mediates vasodilation, neural regulation of skeletal muscle, and neurotransmission.104 Elevated NO levels are implicated in chronic fatigue syndrome,105 fatigue in muscular dystrophies,106,107 and fatigue in post-radiation syndrome.108 Although no studies were identified on associations between NOS polymorphisms and fatigue, other studies found associations between polymorphisms in the NOS1 gene and depression109 and anxiety.110
Anti-fatigue effect by active dipeptides of fermented porcine placenta through inhibiting the inflammatory and oxidative reactions
2016, Biomedicine and PharmacotherapyInvestigation of the effects of vanilloids in chronic fatigue syndrome
2016, Brain Research BulletinCitation Excerpt :Study have shown that oxidative stress is involved in pathophysiology of CFS (Logan and Wong, 2001). In 2000, Pall reported role of peroxynitrite in pathogenesis of CFS (Elevated, 2000). The elevated levels of peroxynitrite causes lipid peroxidation and mitochondrial dysfunction.
Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function
2014, Biochimica et Biophysica Acta - Biomembranes