Pharmacopsychiatry 2009; 42: S69-S78
DOI: 10.1055/s-0029-1202847
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Molecular Mechanisms of Psychostimulant-induced Structural Plasticity

D. M. Dietz 1 , K. C. Dietz 1 , E. J. Nestler 1 , S. J. Russo 1
  • 1Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, USA
Further Information

Publication History

Publication Date:
11 May 2009 (online)

Abstract

Drug addiction is characterized by persistent behavioral and cellular plasticity throughout the brain's reward regions. Among the many neuroadaptations that occur following repeated drug administration are alterations in cell morphology including changes in dendritic spines. While this phenomenon has been well documented, the underlying molecular mechanisms are poorly understood. Here, within the context of drug abuse, we review and integrate several of the established pathways known to regulate synaptic remodeling, and discuss the contributions of neurotrophic and dopamine signaling in mediating this structural plasticity. Finally, we discuss how such upstream mechanisms could regulate actin dynamics, the common endpoint involved in structural remodeling in neurons.

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Correspondence

S. J. Russo

Fishberg Department of Neuroscience

Mount Sinai School of Medicine

One Gustave Levy Place

10029 New York

Phone: 212/659 5917

Fax: 212/659 8510

Email: Scott.Russo@mssm.edu

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