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Int J Sports Med 2010; 31(3): 202-206
DOI: 10.1055/s-0029-1243644
Clinical Sciences

© Georg Thieme Verlag KG Stuttgart · New York

Oxygen Uptake to Work Rate Slope in Children with a Heart, Lung or Muscle Disease

W. G. Groen1 , H. J. Hulzebos1 , P. J. Helders1 , T. Takken1
  • 1UMC Utrecht, Child Development & Exercise Centre, Utrecht, Netherlands
Further Information

Publication History

accepted after revision November 30, 2009

Publication Date:
15 February 2010 (online)

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Abstract

The purposes of this study were all to determine if ΔVO2/ΔWR is dependent on age, body mass, height and fitness and if ΔVO2/ΔWR could discriminate between healthy children and children with a chronic disease that limits O2 delivery or utilization. Four groups were included: muscle disease (Juvenile Dermatomyositis; JDM; n=12), lung disease (Cystic Fibrosis; CF; n=13), Congenital Heart Disease (CHD; (n=13), and healthy children (n=44). All children performed a cardiopulmonary exercise test on a cycle ergometer with respiratory gas analysis. The ΔVO2/ΔWR was determined by linear regression using data from unloaded cycling to peak exercise. No associations were found between the ΔVO2/ΔWR and age, body mass and height in healthy children. ΔVO2/ΔWR was significantly correlated with VO2peak/kg (r=0.44; p<0.01). Children with JDM had lower ΔVO2/ΔWR values than healthy children (p=0.02), and ΔVO2/ΔWR tended to be lower in CHD and higher in CF (p=0.09 and p=0.08, respectively). ΔVO2/ΔWR may be more sensitive for conditions that are characterized by local hypo perfusion (as in JDM), than for conditions that are characterized by impaired oxygen delivery (i. e. CF or CHD).

Key words

exercise test - child - aerobic - anaerobic - oxygen transport

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Correspondence

Dr. Tim Takken

UMC Utrecht, Child Development & Exercise Centre

P O Box 85090

3088AB Utrecht

Netherlands

Phone: +31887554030

Fax: +31887555333

Email: t.takken@umcutrecht.nl

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