Neuropediatrics 2004; 35(3): 190-193
DOI: 10.1055/s-2004-815826
Short Communication

Georg Thieme Verlag KG Stuttgart · New York

MRI Findings in Pediatric Neuro-Behçet's Disease

S. Saltik1 , S. Saip2 , N. Kocer3 , A. Siva2 , C. Yalçinkaya4
  • 1Department of Pediatrics, Social Security Istanbul, Goztepe Education Hospital, Istanbul, Turkey
  • 2Department of Neurology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
  • 3Department of Radiology, Division of Neuroradiology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
  • 4Department of Neurology, Division of Child Neurology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
Further Information

Publication History

Received: February 10, 2003

Accepted after Revision: November 28, 2003

Publication Date:
12 July 2004 (online)

Abstract

Behçet's disease (BD), a systemic vasculitis of unknown cause, affects many organs and systems. Neurological involvement is seen in 5 - 15 % of the patients, and the two major forms of neurological disease seen in BD are central nervous system (CNS) parenchymal involvement and cerebral venous sinus thrombosis. We report a 14-year-old boy with BD who had neuro-parenchymal involvement. The diagnosis of the systemic disease was not made until the onset of the neurological manifestations, which led to an MRI study that revealed findings suggestive of CNS involvement of BD. We therefore emphasize the importance of the localization and appearance of other characteristics of the lesions on MRI in the differential diagnosis of parenchymal neuro-Behçet syndrome.

References

  • 1 Akman-Demir G, Baykan-Kurt B, Serdaroglu P. et al . Seven year follow-up of neurologic involvement in Behçet syndrome.  Arch Neurol. 1996;  53 691-694
  • 2 Al Kawi M Z, Bohlega S, Banna M. MRI findings in neuro-Behçet's disease.  Neurology. 1991;  41 405-408
  • 3 Behçet H. Über rezidivierende, aphthöse, durch ein Virus verursachte Geschwüre am Mund, am Auge und an den Genitalien.  Derm Wochenschr. 1937;  105 1152-1157
  • 4 International Study Group for Behçet's Disease . Criteria for diagnosis of Behçet's disease.  Lancet. 1990;  335 1078-1080
  • 5 Kantarci O, Siva A. Behçet's disease: Diagnosis and management. Noseworthy J Neurological Therapeutics: Principles and Practice. London; Martin Dunitz Publishers 2003 (95): 1084
  • 6 Koçer N, Islak C, Siva A. et al . CNS involvement in neuro-Behçet syndrome: An MRI study.  AJNR Am J Neuroradiol. 1999;  20 1015-1024
  • 7 Kone-Paut I, Bernard J L. Epidemiology of Behçet's diseases in children: A French nationwide survey.  Arthritis Rheum. 1992;  35 190
  • 8 Kone-Paut I, Chabrol B, Riss J M. et al . Neurologic onset of Behçet's disease: A diagnostic enigma in childhood.  J Child Neurol. 1997;  12 237-241
  • 9 Kone-Paut I, Yurdakul S, Bahabri S A. et al . Clinical features of Behçet's disease in children: A collaborative study of 86 cases.  J Pediatr. 1998;  132 721-725
  • 10 Siva A, Kantarci O, Saip S. et al . Behçet's disease: diagnostic and prognostic aspects of neurological involvement.  J Neurol. 2001;  248 95-103
  • 11 Siva A, Yazici H. Nervous system involvement in Behçet's syndrome. Erkan D, Levine S Handbook of Systemic Autoimmune Diseases, The Neurologic Involvement in Systemic Autoimmune Disorders. New York; Elsevier Science B. V. 2004
  • 12 Wechsler B, Vidailhet M, Piette J C. et al . Cerebral venous thrombosis in Behçet's disease: Clinical study and long-term follow-up of 25 cases.  Neurology. 1992;  42 614-618

Sema Saltik

Acıbadem caddesi No. 146

Tibas Park Sitesi H Blok Daire: 9

34660 Uskudar - Istanbul

Turkey

Email: Semasaltik@ixir.com

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