Semin Respir Crit Care Med 2007; 28(1): 128-133
DOI: 10.1055/s-2007-970338
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Novel Therapies for Sarcoidosis

Robert P. Baughman1 , Elyse E. Lower1
  • 1Division of Pulmonary and Critical Care Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio
Further Information

Publication History

Publication Date:
28 February 2007 (online)

ABSTRACT

The treatment of sarcoidosis remains controversial. Corticosteroids remain the cornerstone of therapy, but immunosuppressive, cytotoxic, and immunomodulatory agents have emerged as viable therapeutic options for patients failing or experiencing adverse effects from corticosteroids. Published data are most extensive with methotrexate, but favorable responses have been noted with leflunomide, azathioprine, antimalarial and antimicrobial agents, and tumor necrosis factor-α inhibitors. This review focuses on these novel therapies for sarcoidosis, including indications for use, efficacy, toxicity, and monitoring.

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Robert P BaughmanM.D. 

Division of Pulmonary and Critical Care Medicine, University of Cincinnati Medical Center

231 Bethesda Ave., Cincinnati, OH 45267

Email: Bob.Baughman@uc.edu

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