Ellagitannins from Lagerstroemia speciosa as Activators of Glucose Transport in Fat Cells

 

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Abstract

Glucose transport enhancers were searched for in Lagerstroemia speciosa, a Philippine local herbal medicine used for diabetes mellitus. Bioassay-guided fractionation of the aqueous acetone extract of the leaves afforded three active ellagitannins, lagerstroemin, flosin B and reginin A, identified by NMR and optical rotation. These compounds increased glucose uptake of rat adipocytes, and could be responsible for lowering the blood glucose level.

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Prof. Kazuo Yamasaki

Institute of Pharmaceutical Sciences

Faculty of Medicine

Hiroshima University

1-2-3 Kasumi

Minami-ku

Hiroshima 734-8551

Japan

Email: yamasaki@pharm.hiroshima-u.ac.jp

Fax: +81-82-257-5289