Original Articles: Brief CommunicationA novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism☆
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Cited by (13)
Corticosteroid resistance in asthma: Cellular and molecular mechanisms
2022, Molecular Aspects of MedicineCitation Excerpt :In contrast, blood neutrophils from asthmatic patients treated with GCs produced lower levels of leukotrienes compared to blood neutrophils from untreated asthmatic patients (Caramori and Adcock, 2003). However, in vitro, GCs mediate leukotriene C4 (LTC4) catabolism inducing an LTC4-degrading enzyme, gamma-glutamyl transpeptidase-related enzyme (γ-GTPRE) (Caramori et al., 2019; Caramori and Adcock, 2003; Peters-Golden and Sampson, 2003; Zaitsu et al., 2001). A study has shown that fluticasone propionate (400μg/twice for 16 weeks) decreased serum periostin levels compared to baseline in stable asthma patients.
Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD
2012, European Journal of PharmacologyCitation Excerpt :Furthermore, an in vitro study showed that FP accelerated the conversion of leukotriene C4 (LTC4) to LTD4 and finally leaded to the accelerated degradation of LTC4 to less active LTE4 via LTD4 and this action was observed only after cells were exposed to FP for more than 2 days, suggesting new protein synthesis (Zaitsu et al., 2001). The authors speculated that regular use of FP up-regulates the catabolic process of LTC4 to less active LTE4, and therefore contributes to the antiasthma actions (Zaitsu et al., 2001). Although the inflammatory processes occurring in asthma and COPD are different, we can speculate that in the current in vivo study, stopping ICS therapy after 6 months could have a negative effect on the action of the MRP1 protein substrate LTC4.
Pharmacology of airway inflammation in asthma and COPD
2003, Pulmonary Pharmacology and TherapeuticsCarboxypeptidase A-catalyzed direct conversion of leukotriene C<inf>4</inf> to leukotriene F<inf>4</inf>
2003, Archives of Biochemistry and BiophysicsEfficacy and safety of low-dose fluticasone propionate compared with zafirlukast in patients with persistent asthma
2002, American Journal of MedicineCitation Excerpt :However, similar results have been reported in patients who were symptomatic while receiving short-acting β2-agonists alone (12,15). Although the mechanism of action of inhaled corticosteroids is unknown, they do have several anti-inflammatory effects in the airways, including the inhibition of inflammatory cells and cytokines, as well as the prevention of arachidonic acid formation, which in turn inhibits the synthesis of prostaglandins (cyclooxygenase pathway) and leukotrienes (5-lipoxygenase pathway) (29–33). In contrast, the primary mechanism of action of the leukotriene modifiers (e.g., zafirlukast and zileuton) is to prevent the action of leukotrienes on cells (34).
Loss of response to treatment with leukotriene receptor antagonists but not inhaled corticosteroids in patients over 50 years of age
2002, Annals of Allergy, Asthma and Immunology
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Supported by the Ministry of Education, Science, Sports, and Culture of Japan.