Brief ReportsMalignant melanoma arising in a seborrheic keratosis☆,☆☆
Section snippets
CASE REPORT
A 68-year-old man presented to the dermatology clinic for a general skin screening examination. A pigmented lesion was noted on the right side of his back. The lesion was a 1 × 1 cm, darkly pigmented, hyperkeratotic, stuck-on–appearing plaque with visible horn cysts (Fig 1).At the base of the lesion there was some subtle underlying dermal pigmentation. Excision and histologic examination revealed a nodular malignant
DISCUSSION
The occurrence of a malignant melanoma arising in a seborrheic keratosis is rare. Yakar et al1 presented one such case and concluded that this association was coincidental and did not represent a malignant transformation of the seborrheic keratosis. Jones-Caballero et al2 presented another case and also concluded that this was more likely coincidence than malignant transformation. They did point out that having a benign lesion such as a seborrheic keratosis does not prevent the eventual
References (6)
- et al.
Malignant melanoma appearing in seborrheic keratosis
J Dermatol Surg Oncol
(1984) - et al.
Malignant melanoma appearing in a seborrheic keratosis
Br J Dermatol
(1995) - et al.
Malignant neoplasms associated with seborrheic keratoses
Am J Dermatopathol
(1996)
Cited by (38)
Seborrheic keratosis of the cheek simulating squamous cell carcinoma
2021, International Journal of Surgery Case ReportsCitation Excerpt :Indeed, the malignant transformation of seborrhoeic keratoses is a source of controversy, hence the indisputable interest of anatomopathological examination to confirm or invalidate the diagnosis, especially when the latter present an atypical location or clinical manifestations. Indeed, pathological examination is the only reliable means of diagnosis and should be carried out systematically for a lesion whose benign or malignant nature is debated [5,12,13] and can thus guide the treatment of the lesion. Therefore, pathological examination of any seborrhoeic keratosis should be considered when the lesion has an atypical location or clinical manifestations.
Ethical considerations in alleged dermatologic malpractice
2012, Clinics in DermatologyMalignant melanoma and differential diagnosis of pigmented lesions of the skin
2011, Revista Medica Clinica Las CondesTumors of the epidermis
2009, Weedon's Skin Pathology: Third EditionSeborrheic keratosis with basal clear cells: A distinctive microscopic mimic of melanoma in situ
2006, Journal of the American Academy of DermatologyCitation Excerpt :Melanoma arising in a seborrheic keratosis is a rare occurrence. There are several reports of this association, but most authors believe that it is a coincidence rather than an example of malignant transformation.4-6 In contrast, some reports identify a series of malignant neoplasms associated with seborrheic keratoses.
Clinical presentations of cutaneous melanoma
2005, Facial Plastic Surgery Clinics of North America
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The views and opinions expressed by the authors are not necessarily those of the US Army.
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Reprint requests: Robert Zabel, DO, Department of Medicine, William Beaumont Army Medical Center, 5005 N Piedras St, El Paso, TX 79920-5001.