Transactions of the Twenty-Second Annual Meeting of the Society for Maternal-Fetal MedicineIsolated choroid plexus cyst in low-risk women less than 35 years old☆
Section snippets
Material and methods
A MEDLINE search of the databases of the National Library of Medicine was conducted with the use of the term choroid plexus cyst. Approximately 270 articles have been published on this topic, and approximately 100 of them are on prenatal diagnosis of choroid plexus cysts. We performed a meta-analysis only of articles that met four inclusion criteria. The first criterion was that the study be a prospective trial that had been published in the English language from 1990 through 2000. This time
Results
Thirteen prospective trials were published from 1990 through 2000.11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 Eight of these trials met our inclusion criteria. Table I details included and excluded trials and gives the incidence of trisomy 18 cases in the screened population during the time period.Included trials* Excluded trials† Ghidini et al10 (2000) Gupta et al18 (1995)‡ Brown et al11 (1999) Kupferminc et al19
Comment
Prenatal diagnosis was provided historically to specific high-risk groups for known high-risk problems. The goal of this focus was to have a positive impact on pregnancies that are at a higher risk for complications without potentially increasing the risk to all pregnancies from the testing. The widespread availability of ultrasonography to both high- and low-risk women and the introduction of maternal serum analyte screening in low-risk women has enabled the detection of chromosomal
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Cited by (35)
Isolated choroid plexus cysts and health and developmental outcomes in childhood and adolescence – A systematic review
2023, European Journal of Obstetrics and Gynecology and Reproductive BiologyChoroid Plexus Anomalies: Cysts and Papillomas
2018, Obstetric Imaging: Fetal Diagnosis and Care: Second EditionChoroid plexus anomalies: Cysts and papillomas
2017, Obstetric Imaging: Fetal Diagnosis and Care, 2nd EditionFetal imaging: Executive Summary of a Joint Eunice Kennedy Shriver National Institute of Child Health and Human Development, Society for Maternal-Fetal Medicine, American Institute of Ultrasound in Medicine, American College of Obstetricians and Gynecologists, American College of Radiology, Society for Pediatric Radiology, and Society of Radiologists in Ultrasound Fetal Imaging Workshop
2014, American Journal of Obstetrics and GynecologyCitation Excerpt :Several large studies and a metaanalysis found no cases of trisomy 18 when choroid plexus cysts were isolated; therefore, a targeted scan to look for the findings that are associated with trisomy 18, if not performed at the time of the detection of the choroid plexus cyst, is warranted. Unless there is an increased risk based on other factors, the risk of trisomy 18 is considered low with isolated choroid plexus cysts.36-38 There is no need for ultrasonographic follow up in fetuses with isolated choroid plexus cysts, because the cysts almost always resolve,39 and there is no prognostic importance if they do not.
Follow-up of sonographically detected soft markers for fetal aneuploidy
2013, Seminars in PerinatologyCitation Excerpt :T18 typically includes sonographically evident malformations; it is rare that CPCs are the only finding. Several large studies and a meta-analysis found no cases of T18 when no other sonographic findings were evident.14–16 In another study, it was noted that all cases had other anomalies, provided a comprehensive ultrasound was performed.17
Second-trimester genetic sonogram and soft markers
2011, Ultrasound ClinicsCitation Excerpt :The literature seems to agree that prediction of trisomy 18 based on size of CPC is inappropriate, but many studies report there being larger CPCs in fetuses with trisomy 18. Because it is well known that choroid cysts resolve by approximately 28 weeks, a follow-up ultrasonogram is not recommended unless other anomalies are identified at the same time.26–30 Nuchal thickening is an increase in the skin thickness at the level of the posterior fetal neck.
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